WDR26 - WD repeat domain 26 Gene

中文名称：WD 重复域 26

种属: Homo sapiens

同用名: CDW2; GID7; MIP2; SKDEAS

基因 ID: 80232 | 基因类型: protein coding

关于 WDR26

Cytogenetic location: 1q42.11-q42.12 Genomic coordinates (GRCh38): 1:224,385,146-224,434,797 (from NCBI)

This gene has 16 transcripts (splice variants), 275 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 30.1), esophagus (RPKM 28.6) and 25 other tissues.

功能概要

该基因编码 WD 重复蛋白家族的一个成员。 WD 重复是大约 40 个氨基酸的最小保守区域，通常由 gly-his 和 trp-asp (GH-WD) 括起来，这可能有助于异源三聚体或多蛋白复合物的形成。该家族的成员参与多种细胞过程，包括细胞周期进程、信号转导、细胞凋亡和基因调控。已发现该基因的两个转录变体编码两种不同的亚型。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

WDR26 基因产物(3)

mRNA	Protein	Name
NM_001115113.3	NP_001108585.2	WD repeat-containing protein 26 isoform b
NM_001379403.1	NP_001366332.1	WD repeat-containing protein 26 isoform c
NM_025160.7	NP_079436.4	WD repeat-containing protein 26 isoform a

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	17510365	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	15378603	GOA
located in nucleus	IDA IDA: 通过直接分析推断	29911972	GOA
part of ubiquitin ligase complex	IDA IDA: 通过直接分析推断	29911972	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WDR26 蛋白结构

WD40

0
200
400
600
661 a.a.

蛋白主名

其他名称

WD repeat-containing protein 26

CUL4- and DDB1-associated WDR protein 2

WDR26 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	WDR26	Q9H7D7	AXIN1	Homo sapiens	O15169	Anti Bait CoIP	27098453
种属内	WDR26	Q9H7D7	AXIN1	Homo sapiens	O15169	Anti Tag CoIP	27098453

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Skraban-Deardorff Syndrome

SKDEAS	Intellectual Disability With Seizures, Abnormal Gait, And Distinctive Facial Features
Intellectual Disability-Seizures-Abnormal Gait-Facial Dysmorphism Syndrome	Intellectual Disability, Seizures, Abnormal Gait And Distinctive Facial Features

Chromosome 1q41-Q42 Deletion Syndrome

1q41-Q42 Microdeletion Syndrome	1q41q42 Microdeletion Syndrome
Holoprosencephaly 10, Included	Hpe10, Included
1q41-Q42 Deletion Syndrome	Deletion 1q41-Q42
Monosomy 1q41-Q42	Del(1)(Q41q42)
Monosomy 1q41q42	Chromosome Deletion Syndrome 1q41-Q42
Holoprosencephaly 10

Kbg Syndrome

KBGS	Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies
Short Stature, Characteristic Facies, Macrodontia, Intellectual Disability, And Skeletal Anomalies	Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies
Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome	Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15770	WDR26 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	WDR26	VGNC	VGNC:48358
Macaca mulatta	WDR26	VGNC	VGNC:79315
Bos taurus	WDR26	VGNC	VGNC:36889
Rattus norvegicus	WDR26	RGD	RGD:1565589
Felis catus	WDR26	VGNC	VGNC:67023
Mus musculus	WDR26	MGD	MGI:1923825

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

WDR26 - WD repeat domain 26 Gene

关于 WDR26

功能概要

WDR26 基因产物(3)

WDR26 蛋白结构

WDR26 蛋白互作信息

关联疾病

直系同源

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WDR26 - WD repeat domain 26 Gene

关于 WDR26

功能概要

WDR26 基因产物(3)

WDR26 蛋白结构

WDR26 蛋白互作信息

关联疾病

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直系同源

热门区域

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F

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