1. Gene
  2. SP6 - Sp6 transcription factor Gene

SP6 - Sp6 transcription factor Gene

中文名称:Sp6 转录因子

种属: Homo sapiens

同用名: AI1K; EPFN; KLF14; EPIPROFIN

基因 ID: 80320 | 基因类型: protein coding

关于 SP6

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,844,908-47,876,311 (from NCBI)

This gene has 2 transcripts (splice variants), 186 orthologues and 22 paralogues. Biased expression in placenta (RPKM 11.3), skin (RPKM 2.8) and 6 other tissues.

功能概要

SP6 属于包含 3 个经典锌指 DNA 结合结构域的转录因子家族,该结构域由由 2 个半胱氨酸和 2 个组氨酸 (C2H2 基序) 四面体配位的锌原子组成。这些转录因子与富含 GC 的序列和相关的 GT 和 CACCC 盒结合 (Scohy 等人,2000 [PubMed 11087666]) 。[OMIM 提供,2008 年 3 月]

SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]

SP6 基因产物(2)

mRNA Protein Name
NM_001258248.2 NP_001245177.1 transcription factor Sp6
NM_199262.3 NP_954871.1 transcription factor Sp6
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SP6 蛋白结构

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (270 - 297)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (301 - 323)

  • 0
  • 100
  • 200
  • 300
  • 376 a.a.
蛋白主名 其他名称

transcription factor Sp6

Kruppel-like factor 14

SP6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SP6 Q3SY56 NEK7 Homo sapiens Q8TDX7 32814053
种属内
SP6 Q3SY56 NEK7 Homo sapiens Q8TDX7 32814053
种属内
SP6 Q3SY56 NEK7 Homo sapiens Q8TDX7 32814053
种属内
SP6 Q3SY56 MALSU1 Homo sapiens Q96EH3 32296183
种属内
SP6 Q3SY56 TGFBR2 Homo sapiens P37173 32814053
种属内
SP6 Q3SY56 TGFBR2 Homo sapiens P37173 32814053
种属内
SP6 Q3SY56 TGFBR2 Homo sapiens P37173 32814053
种属内
SP6 Q3SY56 PRKACA Homo sapiens P17612 32814053
种属内
SP6 Q3SY56 PRKACA Homo sapiens P17612 32814053
种属内
SP6 Q3SY56 PRKACA Homo sapiens P17612 32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]

Hermansky-Pudlak Syndrome 6

HPS6

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

Delta Storage Pool Disease

Hermansky-Pudlak Syndrome, Type 6

Platelet Storage Pool Deficiency

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Premenstrual Tension

Premenstrual Syndrome

Pmt - [Premenstrual Tension]

Premenstrual Tension Nos

Syndrome Of Menstruation

Brain Stem Infarction

Brain Stem Infarctions

Brainstem Infarction

Lesion Of Sciatic Nerve

Nerve Lesion Sciatic

Sciatic Neuropathy

Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus SP6 VGNC VGNC:65588
Canis familiaris SP6 VGNC VGNC:46689
Macaca mulatta SP6 VGNC VGNC:77922
Bos taurus SP6 VGNC VGNC:35156
Mus musculus SP6 MGD MGI:1932575
Rattus norvegicus SP6 RGD RGD:1306768
Others SP6 NCBI