2. Gene
  3. DUSP16 - dual specificity phosphatase 16 Gene

DUSP16 - dual specificity phosphatase 16 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：双特异性磷酸酶 16

种属: Homo sapiens

同用名: MKP7; MKP-7

基因 ID: 80824 | 基因类型: protein coding

关于 DUSP16

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:12,473,282-12,562,863 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 203 orthologues and 30 paralogues. Ubiquitous expression in adrenal (RPKM 19.6), liver (RPKM 13.0) and 25 other tissues.

功能概要

该基因编码的丝裂原活化蛋白激酶磷酸酶是双特异性蛋白磷酸酶亚家族的成员。这些磷酸酶通过使磷酸丝氨酸/苏氨酸和磷酸酪氨酸残基去磷酸化来灭活它们的靶激酶。编码的蛋白质特异性调节 c-Jun 氨基末端激酶 (JNK) 和细胞外信号调节激酶 (ERK) 通路。[RefSeq 提供，2010 年 5 月]

This gene encodes a mitogen-activated protein kinase Phosphatase that is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]

DUSP16 基因产物(1)

mRNA Protein Name
NM_030640.3 NP_085143.1 dual specificity protein phosphatase 16
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables JUN kinase binding IPI
IPI: 通过物理相互作用推断
11489891 GOA
enables mitogen-activated protein kinase binding IPI
IPI: 通过物理相互作用推断
11489891 GOA
enables mitogen-activated protein kinase p38 binding IDA
IDA: 通过直接分析推断
11489891 GOA
enables phosphatase activity IDA
IDA: 通过直接分析推断
11489891 GOA
enables phosphoprotein phosphatase activity IMP
IMP: 通过突变表型推断
11489891 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20936779 GOA
enables protein carrier chaperone IDA
IDA: 通过直接分析推断
11489891 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in dephosphorylation IDA
IDA: 通过直接分析推断
24531476 GOA
acts upstream of or within negative regulation of MAPK cascade IDA
IDA: 通过直接分析推断
11489891 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11489891 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11489891 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DUSP16 蛋白结构

Rhodanese

Rhodanese: Rhodanese-like domain (16 - 123)

  • 0
  • 100
  • 143 a.a.
蛋白主名 其他名称

dual specificity protein phosphatase 16

MAP kinase phosphatase 7

DUSP16 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DUSP16 Q9BY84 MAPK8 Homo sapiens P45983-4
Y2H Array
32296183
种属内
DUSP16 Q9BY84 MAPK8 Homo sapiens P45983-4
Y2H Prey Pooling
32296183
种属内
DUSP16 Q9BY84 MAPK9 Homo sapiens P45984
Anti Tag CoIP
33961781
种属内
DUSP16 Q9BY84 MAPK9 Homo sapiens P45984
Y2H Array
32296183
种属内
DUSP16 Q9BY84 MAPK9 Homo sapiens P45984
Anti Tag CoIP
27880917
种属内
DUSP16 Q9BY84 MAPK9 Homo sapiens P45984
Y2H Prey Pooling
32296183
种属内
DUSP16 Q9BY84 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属内
DUSP16 Q9BY84 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
DUSP16 Q9BY84 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属内
DUSP16 Q9BY84 MAPK14 Homo sapiens Q16539
Anti Tag CoIP
27880917
种属内
DUSP16 Q9BY84 MAPK14 Homo sapiens Q16539
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chronic Polyneuropathy
Vulvar Sarcoma

Sarcoma Of Vulva

Vulva Sarcoma
Inclusion Conjunctivitis

Chlamydial Conjunctivitis

Inclusion Blennorrhoea

Paratrachoma

Adult Inclusion Conjunctivitis

Inclusion Blenorrhea

Conjunctivitis, Inclusion

Neonatal Chlamydial Conjunctivitis

Inclusion Conjunctivitis Of The Adult

Chronic Conjunctivitis Due To Chlamydia Trachomatis

Inclusion Conjunctivitis Due To Chlamydia Trachomatis

Acute Follicular Conjunctivitis, Chlamydial

Adult Chlamydial Keratoconjunctivitis
Obstructive Hydrocephalus
Polymicrogyria, Bilateral Perisylvian, X-Linked

Bilateral Perisylvian Polymicrogyria

Polymicrogyria, Bilateral Perisylvian

Pmgx

Perisylvian Syndrome, Congenital Bilateral

Cbps

Congenital Bilateral Perisylvian Syndrome

Perisylvian Syndrome

BPPX

Bpp
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04057 DUSP16 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DUSP16 RGD RGD:1310721
Canis familiaris DUSP16 VGNC VGNC:40130
Felis catus DUSP16 VGNC VGNC:61664
Macaca mulatta DUSP16 VGNC VGNC:71855
Mus musculus DUSP16 MGD MGI:1917936
Bos taurus DUSP16 VGNC VGNC:28253
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