TAF15 - TATA-box binding protein associated factor 15 Gene

中文名称：TATA-box 结合蛋白相关因子 15

种属: Homo sapiens

同用名: Npl3; RBP56; TAF2N; TAFII68

基因 ID: 8148 | 基因类型: protein coding

关于 TAF15

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,809,484-35,847,242 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele, 199 orthologues, 2 paralogues and is associated with 4 phenotypes. Ubiquitous expression in testis (RPKM 46.3), lymph node (RPKM 45.2) and 25 other tissues.

功能概要

该基因编码 RNA 结合蛋白 TET 家族的成员。编码的蛋白质作为多亚基转录起始因子 TFIID 复合物的一个独特子集的组成部分，在 RNA 聚合酶 II 基因转录中发挥作用。涉及该基因的易位在急性白血病和骨骼外粘液样软骨肉瘤中起作用，而该基因的突变可能在肌萎缩侧索硬化中起作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 5 月]

This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

TAF15 基因产物(2)

mRNA	Protein	Name
NM_003487.4	NP_003478.1	TATA-binding protein-associated factor 2N isoform 2
NM_139215.3	NP_631961.1	TATA-binding protein-associated factor 2N isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA binding	IDA IDA: 通过直接分析推断	27378374	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	18509338	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within mRNA stabilization	IDA IDA: 通过直接分析推断	27378374	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	19124016	GOA
NOT located in nucleolus	IDA IDA: 通过直接分析推断	19124016	GOA
located in nucleus	IDA IDA: 通过直接分析推断	19124016	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TAF15 蛋白结构

RRM_1

zf-RanBP

0
100
200
300
400
500
589 a.a.

蛋白主名

其他名称

TATA-binding protein-associated factor 2N

RBP56/CSMF fusion

TAF15 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TAF15	Q92804	KAT5	Homo sapiens	Q92993	Pull Down	18509338
种属内	TAF15	Q92804	FUS	Homo sapiens	P35637	Pull Down	23975937
种属内	TAF15	Q92804	FUS	Homo sapiens	P35637	Y2H	21988832

种属间: 跨种属相互作用 种属内: 同种属相互作用

TAF15 抗体

目录号	产品名	应用	反应物种
HY-P82389	TAF15 Antibody (YA2134)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat

关联疾病

疾病名称

别名

Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma	Emc
Myxoid Extraosseous Chondrosarcoma

Myxoid Chondrosarcoma

Chondrosarcoma

Cartilaginous Cancer	Chondrosarcoma Of Bone
Primary Chondrosarcoma Of The Bone	CHDSA

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Extraosseous Chondrosarcoma

Extraskeletal Myxoid Chondrosarcoma

Liposarcoma

Lipomatous Cancer

Acute Leukemia

Stem Cell Leukaemia	Stem Cell Leukemia
Acute Leukemias	Acute Undifferentiated Leukemia
Undifferentiated Leukemia	Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission
Blast Cell Leukaemia	Blast Leukaemia
Blastic Leukaemia	Undifferentiated Leukaemia

Parachordoma

Extraskeletal Mesenchymal Chondrosarcoma

Mesenchymal Extraosseous Chondrosarcoma

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 1

Ibmpfd1	Msp1
Multisystem Proteinopathy 1

Sclerosing Liposarcoma

Bone Chondrosarcoma

Soft Tissue Chondroma

Extraskeletal Chondroma

Intracranial Chondrosarcoma

Lung Sarcoma

Pulmonary Sarcoma

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma	Liposarcoma, Myxoid
Mrcls	Myxoliposarcoma
MXLIPO	Liposarcoma Myxoid
Liposarcoma

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1	Frontotemporal Dementia And/Or Motor Neuron Disease
Ftdmnd	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia
Alsftd	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1	Frontotemporal Dementia With Motor Neuron Disease
Ftdals	Ftd-Als
Ftd-Mnd	Frontotemporal Dementia With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1	Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1
Frontotemporal Lobar Degeneration	Grn-Related Frontotemporal Dementia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14162	TAF15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	TAF15	VGNC	VGNC:104662
Rattus norvegicus	TAF15	RGD	RGD:1309595
Felis catus	TAF15	VGNC	VGNC:65926
Bos taurus	TAF15	VGNC	VGNC:54497
Mus musculus	TAF15	MGD	MGI:1917689
Canis familiaris	TAF15	VGNC	VGNC:47076
Others	TAF15	NCBI

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上海工商

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营业执照（三证合一）

TAF15 - TATA-box binding protein associated factor 15 Gene

关于 TAF15

功能概要

TAF15 基因产物(2)

TAF15 蛋白结构

TAF15 蛋白互作信息

TAF15 抗体

关联疾病

直系同源

热门区域

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TAF15 - TATA-box binding protein associated factor 15 Gene

关于 TAF15

功能概要

TAF15 基因产物(2)

TAF15 蛋白结构

TAF15 蛋白互作信息

TAF15 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z