1. Gene
  2. GRB2 - Grb2 growth factor receptor bound protein 2 Gene

GRB2 - Grb2 growth factor receptor bound protein 2 Gene

种属: Rattus norvegicus

同用名: Ash-psi

基因 ID: 81504 | 基因类型: protein coding

关于 GRB2

功能概要

Enables several functions, including epidermal growth factor receptor binding activity; Insulin Receptor substrate binding activity; and phosphotyrosine residue binding activity. Involved in aging. Part of protein-containing complex. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate Cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2). [provided by Alliance of Genome Resources, Apr 2022]

GRB2 基因产物(1)

mRNA Protein Name
NM_030846.2 NP_110473.2 growth factor receptor-bound protein 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
9259313 RGD
enables epidermal growth factor receptor binding IPI
IPI: 通过物理相互作用推断
21258655 RGD
enables insulin receptor substrate binding IPI
IPI: 通过物理相互作用推断
12891559 RGD
enables phosphoprotein binding IPI
IPI: 通过物理相互作用推断
8910399 RGD
enables phosphotyrosine residue binding IPI
IPI: 通过物理相互作用推断
9271418 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
8940134 RGD
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
10973965 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
15272025 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in presynapse IDA
IDA: 通过直接分析推断
8022809 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
10973965 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

growth factor receptor-bound protein 2

SH2/SH3 adapter GRB2

adapter protein GRB2

growth factor receptor-bound protein 2-like

protein Ash

GRB2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross Grb2 P62994 PDE6G Homo sapiens P18545
Y2H
16357825
Cross Grb2 P62994 PTPN1 Homo sapiens P18031
Pull Down
8940134
Cross Grb2 P62994 PTPN1 Homo sapiens P18031
Pull Down
12023880
Intra Grb2 P62994 Ntrk1 Rattus norvegicus P35739
Y2H
10748052
Intra Grb2 P62994 Ntrk1 Rattus norvegicus P35739
Pull Down
10748052
Intra Grb2 P62994 Ntrk1 Rattus norvegicus P35739
CoIP
10748052
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens GRB2 NCBI NCBI:2885