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  3. Alox15 - arachidonate 15-lipoxygenase Gene

Alox15 - arachidonate 15-lipoxygenase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：花生四烯酸 15-脂氧合酶

种属: Rattus norvegicus

同用名: 12-LOX; 15-LOX; Alox12; Alox12l

基因 ID: 81639 | 基因类型: protein coding

关于 Alox15

Primary_assembly 10: 55,060,412-55,068,874 reverse strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 168 orthologues, 6 paralogues and is associated with 22 phenotypes. Biased expression in Spleen (RPKM 287.1), Lung (RPKM 941.1) and 1 other tissue.

功能概要

该基因编码的蛋白可启动 hepoxilin A3 合酶活性；肝素环氧化物水解酶活性；和氧化还原酶活性，作用于结合分子氧、结合两个氧原子的单一供体。参与脂肪酸代谢过程和异型细胞间粘附的正调控。位于胞质溶胶中。脑缺血的生物标志物；充血性心力衰竭;和肾小球肾炎。与人类 ALOX15（花生四烯酸 15-脂氧合酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables hepoxilin A3 synthase activity; hepoxilin-epoxide hydrolase activity; and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in fatty acid metabolic process and positive regulation of heterotypic cell-cell adhesion. Located in cytosol. Biomarker of brain ischemia; congestive heart failure; and glomerulonephritis. Orthologous to human ALOX15 (arachidonate 15-lipoxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Alox15 基因产物(1)

mRNA Protein Name
NM_031010.2 NP_112272.2 polyunsaturated fatty acid lipoxygenase ALOX15
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables arachidonate 12(S)-lipoxygenase activity IDA
IDA: 通过直接分析推断
8117750 RGD
enables arachidonate 15-lipoxygenase activity IDA
IDA: 通过直接分析推断
8444196 RGD
enables hepoxilin A3 synthase activity IDA
IDA: 通过直接分析推断
15123652 RGD
enables hepoxilin-epoxide hydrolase activity IDA
IDA: 通过直接分析推断
15123652 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in arachidonate metabolic process IDA
IDA: 通过直接分析推断
8117750 RGD
involved in hepoxilin biosynthetic process IDA
IDA: 通过直接分析推断
15123652 RGD
involved in lipoxygenase pathway IDA
IDA: 通过直接分析推断
8117750 RGD
involved in positive regulation of heterotypic cell-cell adhesion IMP
IMP: 通过突变表型推断
15576842 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
15123652 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Alox15 蛋白结构

PLAT

PLAT: cl00011 (137 - 204)

Lipoxygenase

Lipoxygenase: cl37981 (294 - 746)

  • 0
  • 200
  • 400
  • 600
  • 756 a.a.
蛋白主名 其他名称

polyunsaturated fatty acid lipoxygenase ALOX15

12/15-LOX

12/15-lipoxygenase

arachidonate 12-lipoxygenase, leukocyte-type

arachidonate omega-6 lipoxygenase

hepoxilin A3 synthase Alox15

linoleate 13S-lipoxygenase

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-143791 ALOX15-IN-2 Inhibitor 99.88% 否
HY-143787 ALOX15-IN-1 Inhibitor 98.09% 否
HY-RS00616 ALOX15 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00617 Alox15 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00618 Alox15 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00619 ALOX15B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Alox15 NCBI NCBI:246
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