1. Gene
  2. CCNL2 - cyclin L2 Gene

CCNL2 - cyclin L2 Gene

中文名称:细胞周期素 L2

种属: Homo sapiens

同用名: CCNM; CCNS; PCEE; SB138; ANIA-6B; HLA-ISO; HCLA-ISO

基因 ID: 81669 | 基因类型: protein coding

关于 CCNL2

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,385,711-1,399,335 (from NCBI)

This gene has 19 transcripts (splice variants), 145 orthologues and 6 paralogues. Ubiquitous expression in skin (RPKM 45.3), endometrium (RPKM 44.2) and 25 other tissues.

功能概要

该基因编码的蛋白质属于细胞周期蛋白家族。通过与多种蛋白质 (如 RNA 聚合酶 II、剪接因子和细胞周期蛋白依赖性激酶) 的相互作用,该蛋白质可作为 pre-mRNA 剪接过程的调节剂,以及通过调节细胞凋亡和抗细胞凋亡的表达来诱导细胞凋亡蛋白质。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供,2011 年 8 月]

The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing Apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

CCNL2 基因产物(8)

mRNA Protein Name
NM_001039577.5 NP_001034666.1 cyclin-L2 isoform B
NM_001320153.3 NP_001307082.1 cyclin-L2 isoform C
NM_001320155.3 NP_001307084.1 cyclin-L2 isoform C
NM_001350497.1 NP_001337426.1 cyclin-L2 isoform C
NM_001350498.2 NP_001337427.1 cyclin-L2 isoform C
NM_001350499.2 NP_001337428.1 cyclin-L2 isoform D
NM_001350500.2 NP_001337429.1 cyclin-L2 isoform D
NM_030937.6 NP_112199.2 cyclin-L2 isoform A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of RNA splicing IDA
IDA: 通过直接分析推断
18216018 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: 通过物理相互作用推断
18216018 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17494991 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CCNL2 蛋白结构

Cyclin_N

Cyclin_N: Cyclin, N-terminal domain (72 - 191)

Cyclin_C

Cyclin_C: Cyclin, C-terminal domain (215 - 288)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 520 a.a.
蛋白主名 其他名称

cyclin-L2

cyclin M

CCNL2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CCNL2 Q96S94 RUNDC3A Homo sapiens Q59EK9 25416956
种属内
CCNL2 Q96S94 RUNDC3A Homo sapiens Q59EK9 25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome

Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

Syndactyly With Renal And Anogenital Malformations

STAR

Syndactyly, Telecanthus, Anogenital And Renal Malformations

Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

Jalili Syndrome

Cone-Rod Dystrophy And Amelogenesis Imperfecta

Cone Rod Dystrophy-Amelogenesis Imperfecta Syndrome

Cone-Rod Dystrophy Amelogenesis Imperfecta

Cone-Rod Dystrophy With Amelogenesis Imperfecta

JALIS

Cone Rod Dystrophy Amelogenesis Imperfecta

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Townes-Brocks Syndrome

Townes Syndrome

Renal-Ear-Anal-Radial Syndrome

Anus, Imperforate, With Hand, Foot And Ear Anomalies

Imperforate Anus-Hand, Foot And Ear Anomalies Syndrome

Rear Syndrome

Sensorineural Deafness With Imperforate Anus And Hypoplastic Thumbs

Tbs

Deafness, Sensorineural, With Imperforate Anus And Hypoplastic Thumbs

Imperforate Anus With Hand, Foot And Ear Anomalies

Anal-Ear-Renal-Radial Malformation Syndrome

Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome

Imperforate Anus-Hand And Foot Anomalies Syndrome

Sensorineural Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome

Sensorineural Hearing Loss With Imperforate Anus And Hypoplastic Thumbs

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CCNL2 VGNC VGNC:80161
Canis familiaris CCNL2 VGNC VGNC:38905
Bos taurus CCNL2 VGNC VGNC:26976
Rattus norvegicus CCNL2 RGD RGD:1309149
Mus musculus CCNL2 MGD MGI:1927119