2. Gene
  3. Mmp14 - matrix metallopeptidase 14 Gene

Mmp14 - matrix metallopeptidase 14 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：基质金属肽酶 14

种属: Rattus norvegicus

同用名: Mt1-mmp

基因 ID: 81707 | 基因类型: protein coding

关于 Mmp14

Primary_assembly 15: 27,887,727-27,899,864 forward strand.mRatBN7.2:CM026988.1

This gene has 3 transcripts (splice variants), 272 orthologues, 23 paralogues and is associated with 34 phenotypes. Biased expression in Uterus (RPKM 594.1), Adrenal (RPKM 38.8) and 9 other tissues.

功能概要

该基因编码的蛋白可启动整合素结合活动。参与多个过程，包括性腺发育；粘着斑组装的负调控；以及对气味的反应。位于细胞质中。用于研究缺血。 IgA 肾小球肾炎的生物标志物；抗基底膜肾小球肾炎；动脉疾病（多发性）；脑缺血;和充血性心力衰竭。该基因的人类直系同源物与温彻斯特综合征有关；食道腺癌；和心肌梗塞。与人 MMP14（基质金属肽酶 14）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Integrin binding activity. Involved in several processes, including gonad development; negative regulation of focal adhesion assembly; and response to odorant. Located in cytoplasm. Used to study ischemia. Biomarker of IgA glomerulonephritis; anti-basement membrane glomerulonephritis; artery disease (multiple); brain ischemia; and congestive heart failure. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14). [provided by Alliance of Genome Resources, Apr 2022]

Mmp14 基因产物(1)

mRNA Protein Name
NM_031056.1 NP_112318.1 matrix metalloproteinase-14 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables integrin binding IPI
IPI: 通过物理相互作用推断
19027888 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in angiogenesis IEP
IEP: 通过表达模式推断
14766216 RGD
involved in astrocyte cell migration IEP
IEP: 通过表达模式推断
16265672 RGD
involved in endothelial cell proliferation IEP
IEP: 通过表达模式推断
14766216 RGD
involved in male gonad development IEP
IEP: 通过表达模式推断
22152881 RGD
involved in negative regulation of focal adhesion assembly IDA
IDA: 通过直接分析推断
15044209 RGD
involved in ossification IEP
IEP: 通过表达模式推断
15883642 RGD
involved in ovarian follicle development IEP
IEP: 通过表达模式推断
15617683 RGD
involved in positive regulation of protein processing IMP
IMP: 通过突变表型推断
14668206 RGD
involved in response to estrogen IEP
IEP: 通过表达模式推断
15053235 RGD
involved in response to hormone IDA
IDA: 通过直接分析推断
14668206 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
16980344 RGD
involved in response to mechanical stimulus IEP
IEP: 通过表达模式推断
15350851 RGD
involved in response to odorant IEP
IEP: 通过表达模式推断
23103411 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
11125539 RGD
involved in response to oxidative stress IEP
IEP: 通过表达模式推断
15642321 RGD
involved in tissue remodeling IDA
IDA: 通过直接分析推断
16740171 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mmp14 蛋白结构

PG_binding_1

PG_binding_1: pfam01471 (35 - 87)

Peptidase_M10

Peptidase_M10: pfam00413 (117 - 283)

HX

HX: cd00094 (315 - 507)

DUF3377

DUF3377: cl13321 (559 - 581)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 582 a.a.
蛋白主名 其他名称

matrix metalloproteinase-14

MMP-14

MT-MMP 1

MT1MMP

MTMMP1

matrix metallopeptidase 14 (membrane-inserted)

matrix metalloproteinase 14 membrane-inserted

membrane type 1-matrix metalloproteinase

membrane-type matrix metalloproteinase 1

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-12169 Marimastat Inhibitor ≥98.0% Phase 3
Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15827 NSC 405020 Inhibitor 99.67% 否
HY-110397 KP-457 Inhibitor 99.18% 否
HY-107394 UK 356618 Inhibitor 98.91% 否
HY-107639 UK-370106 Inhibitor ≥99.0% 否
HY-124373 ND-336 Inhibitor 95.4% 否
HY-P3120 Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 96.30% 否
HY-110397G KP-457 (GMP) Inhibitor / 否
HY-114785 BPHA Inhibitor / 否
HY-124373A (R)-ND-336 Inhibitor / 否
HY-162038 RXP03 Inhibitor / 否
HY-E70290 N-Acetylgalactosaminyltransferase 1 Agonist / 否
HY-RS08528 MMP14 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08529 Mmp14 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08530 Mmp14 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mmp14 NCBI NCBI:4323
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