Nfkb1 - nuclear factor kappa B subunit 1 Gene

中文名称：核因子 κB 亚基 1

种属: Rattus norvegicus

同用名: EBP-1; NF-kB

关于 Nfkb1

功能概要

该基因编码的蛋白可启动热休克蛋白结合活性；相同的蛋白质结合活性；和转录顺式调节区结合活性。参与多个过程，包括细胞对细胞因子刺激的反应；细胞对脂质的反应；和基因表达的调控。在对细胞因子刺激的细胞反应和对有机环状化合物的细胞反应的上游或内部起作用。位于胞质溶胶中；神经元投射；和核。部分含蛋白质复合物。用于研究脂肪肝疾病。酒精性肝炎的生物标志物；非酒精性脂肪性肝炎；和短暂性脑缺血。该基因的人类直系同源物与多种疾病有关，包括癌（多种）；常见变异型免疫缺陷；黑色素瘤;前列腺癌;和热带痉挛性轻瘫。与人类 NFKB1（核因子 kappa B 亚基 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables heat shock protein binding activity; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and regulation of gene expression. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in cytosol; neuron projection; and nucleus. Part of protein-containing complex. Used to study fatty liver disease. Biomarker of alcoholic hepatitis; non-alcoholic steatohepatitis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Apr 2022]