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  3. P2rx3 - purinergic receptor P2X 3 Gene

P2rx3 - purinergic receptor P2X 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：嘌呤能受体 P2 X 3

种属: Rattus norvegicus

基因 ID: 81739 | 基因类型: protein coding

关于 P2rx3

Primary_assembly 3: 70,080,851-70,125,178 reverse strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 275 orthologues, 6 paralogues and is associated with 2 phenotypes. Biased expression in Kidney (RPKM 11.6), Adrenal (RPKM 5.2) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多项功能，包括 ATP 绑定活动；细胞外 ATP 门控阳离子通道活性；和相同的蛋白质结合活性。涉及多个过程，包括对福尔马林引起的疼痛的行为反应；神经元动作电位；以及对疼痛感觉的正向调节。位于多个细胞成分中，包括树突棘；膜筏；和粗面内质网。是质膜的组成部分。是突触前膜的组成部分。与人 P2RX3（嘌呤能受体 P2X 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and identical protein binding activity. Involved in several processes, including behavioral response to formalin induced pain; neuronal action potential; and positive regulation of sensory perception of pain. Located in several cellular components, including dendritic spine; membrane raft; and rough endoplasmic reticulum. Is integral component of plasma membrane. Is integral component of presynaptic membrane. Orthologous to human P2RX3 (purinergic receptor P2X 3). [provided by Alliance of Genome Resources, Apr 2022]

P2rx3 基因产物(2)

mRNA Protein Name
NM_001270621.1 NP_001257550.1 P2X purinoceptor 3 isoform 2
NM_031075.2 NP_112337.2 P2X purinoceptor 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
12581826 RGD
enables extracellularly ATP-gated monoatomic cation channel activity IDA
IDA: 通过直接分析推断
7566119 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15313628 RGD
enables purinergic nucleotide receptor activity IDA
IDA: 通过直接分析推断
7566119 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in behavioral response to formalin induced pain IMP
IMP: 通过突变表型推断
24120766 RGD
involved in cellular response to ATP IDA
IDA: 通过直接分析推断
7566119 RGD
involved in neuronal action potential IDA
IDA: 通过直接分析推断
12581826 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendritic spine IDA
IDA: 通过直接分析推断
9721930 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
9721930 RGD
located in plasma membrane IMP
IMP: 通过突变表型推断
7566119 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
26801076 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
9721930 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

P2rx3 蛋白结构

P2X_receptor

P2X_receptor: pfam00864 (26 - 378)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
蛋白主名 其他名称

P2X purinoceptor 3

ATP receptor

P2X3

purinergic receptor P2X, ligand-gated ion channel, 3

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09903 P2RX3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09904 P2rx3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09905 P2rx3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens P2rx3 NCBI NCBI:5024
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