2. Gene
  3. Pde2a - phosphodiesterase 2A Gene

Pde2a - phosphodiesterase 2A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 2A

种属: Rattus norvegicus

同用名: Pde2; Pde2a2; CGS-PDE

基因 ID: 81743 | 基因类型: protein coding

关于 Pde2a

Primary_assembly 1: 155,813,180-155,915,434 forward strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 215 orthologues, 20 paralogues and is associated with 9 phenotypes. Biased expression in Brain (RPKM 258.3), Adrenal (RPKM 218.3) and 8 other tissues.

功能概要

实现相同的蛋白质结合活性。参与多个过程，包括建立内皮屏障；负调节 cAMP 介导的信号；和对硫化氢的反应。位于多种细胞成分中，包括海马苔藓纤维；膜筏；和线粒体。心肌病的生物标志物。与人 PDE2A（磷酸二酯酶 2A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity. Involved in several processes, including establishment of endothelial barrier; negative regulation of cAMP-mediated signaling; and response to hydrogen sulfide. Located in several cellular components, including hippocampal mossy fiber; membrane raft; and mitochondrion. Biomarker of cardiomyopathy. Orthologous to human PDE2A (phosphodiesterase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Pde2a 基因产物(3)

mRNA Protein Name
NM_001270604.2 NP_001257533.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1
NM_001143847.2 NP_001137319.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3
NM_031079.2 NP_112341.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
12573460 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
17329248 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in establishment of endothelial barrier IDA
IDA: 通过直接分析推断
20139324 RGD
involved in intracellular signal transduction IMP
IMP: 通过突变表型推断
28463107 RGD
involved in negative regulation of cAMP/PKA signal transduction IDA
IDA: 通过直接分析推断
12107056 RGD
involved in regulation of mitochondrion organization IMP
IMP: 通过突变表型推断
28463107 RGD
involved in response to hydrogen sulfide IEP
IEP: 通过表达模式推断
24012591 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19506089 RGD
located in hippocampal mossy fiber IDA
IDA: 通过直接分析推断
19506089 RGD
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
28463107 RGD
located in mitochondrial matrix IDA
IDA: 通过直接分析推断
21724846 RGD
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
28463107 RGD
located in mitochondrion IDA
IDA: 通过直接分析推断
28463107 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
28463107 RGD
located in synaptic membrane IDA
IDA: 通过直接分析推断
12573460 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pde2a 蛋白结构

GAF

GAF: smart00065 (234 - 381)

GAF

GAF: smart00065 (403 - 552)

PDEase_I

PDEase_I: pfam00233 (649 - 882)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 935 a.a.
蛋白主名 其他名称

cGMP-dependent 3',5'-cyclic phosphodiesterase

cyclic GMP-stimulated phosphodiesterase

phosphodiesterase 2A, cGMP-stimulated

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-111371 PF-05180999 Inhibitor 99.97% Phase 1
HY-103493 TAK-915 Inhibitor 99.74% Phase 1
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-102050 PF-05085727 Inhibitor 99.60% 否
HY-132993 Hcyb1 Inhibitor 98.20% 否
HY-120710 DNS-8254 Inhibitor / 否
HY-142660 PDE2A-IN-1 Inhibitor / 否
HY-RS10213 PDE2A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10214 Pde2a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10215 Pde2a Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-124173 PF-06815189 Inhibitor / 否
HY-112704 PDE5-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pde2a NCBI NCBI:5138
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