2. Gene
  3. PDE2A - phosphodiesterase 2A Gene

PDE2A - phosphodiesterase 2A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 2A

种属: Homo sapiens

同用名: PDE2A1; PED2A4; cGSPDE; CGS-PDE; IDDPADS

基因 ID: 5138 | 基因类型: protein coding

关于 PDE2A

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,576,141-72,674,422 (from NCBI)

This gene has 27 transcripts (splice variants), 215 orthologues, 20 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 45.0), brain (RPKM 27.8) and 14 other tissues.

功能概要

启用多种功能，包括 3',5'-环状核苷酸磷酸二酯酶活性；阴离子结合活性；和金属离子结合活性。参与多个过程，包括细胞对有机环状化合物的反应；环核苷酸介导的信号；和调节血管通透性。位于几种细胞成分中，包括细胞质；线粒体膜；和细胞质的核周区。与质膜共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including 3',5'-cyclic-nucleotide phosphodiesterase activity; anion binding activity; and metal ion binding activity. Involved in several processes, including cellular response to organic cyclic compound; cyclic-nucleotide-mediated signaling; and regulation of vascular permeability. Located in several cellular components, including cytosol; mitochondrial membrane; and perinuclear region of cytoplasm. Colocalizes with plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PDE2A 基因产物(5)

mRNA Protein Name
NM_001146209.3 NP_001139681.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A4
NM_002599.5 NP_002590.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3
NM_001243784.2 NP_001230713.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1
XM_005274040.4 XP_005274097.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1
NM_001143839.4 NP_001137311.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IDA
IDA: 通过直接分析推断
17329248 GOA
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
9210593 GOA
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
9210593 GOA
enables TPR domain binding IPI
IPI: 通过物理相互作用推断
17329248 GOA
enables cAMP binding IMP
IMP: 通过突变表型推断
15938621 GOA
enables cGMP binding IDA
IDA: 通过直接分析推断
17329248 GOA
enables cGMP binding IMP
IMP: 通过突变表型推断
15938621 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
19828435 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
15938621 GOA
enables phosphate ion binding IDA
IDA: 通过直接分析推断
15938621 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17329248 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
19828435 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
15938621 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
17329248 GOA
involved in cAMP-mediated signaling IMP
IMP: 通过突变表型推断
17704206 GOA
involved in cGMP catabolic process IDA
IDA: 通过直接分析推断
19828435 GOA
involved in cGMP-mediated signaling IMP
IMP: 通过突变表型推断
17704206 GOA
involved in cellular response to 2,3,7,8-tetrachlorodibenzodioxine IDA
IDA: 通过直接分析推断
17329248 GOA
involved in cellular response to cAMP IDA
IDA: 通过直接分析推断
17329248 GOA
involved in cellular response to cGMP IDA
IDA: 通过直接分析推断
17704206 GOA
involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
IDA: 通过直接分析推断
14687666 GOA
involved in cellular response to macrophage colony-stimulating factor stimulus IDA
IDA: 通过直接分析推断
14687666 GOA
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
17704206 GOA
involved in cellular response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
14687666 GOA
involved in monocyte differentiation IEP
IEP: 通过表达模式推断
14687666 GOA
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
19252089 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17329248 GOA
involved in negative regulation of vascular permeability IMP
IMP: 通过突变表型推断
17704206 GOA
involved in positive regulation of vascular permeability IMP
IMP: 通过突变表型推断
17704206 GOA
involved in regulation of cAMP-mediated signaling IMP
IMP: 通过突变表型推断
15938621 GOA
involved in regulation of cGMP-mediated signaling IMP
IMP: 通过突变表型推断
15938621 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10375378 GOA
located in cytosol IDA
IDA: 通过直接分析推断
17329248 GOA
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
28463107 GOA
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
28463107 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10375378 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
10375378 GOA
colocalizes with plasma membrane IDA
IDA: 通过直接分析推断
17329248 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
19252089 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDE2A 蛋白结构

GAF

GAF: GAF domain (248 - 367)

GAF

GAF: GAF domain (409 - 548)

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (655 - 892)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 941 a.a.
蛋白主名 其他名称

cGMP-dependent 3',5'-cyclic phosphodiesterase

cGMP-stimulated phosphodiesterase 1

cGMP-stimulated phosphodiesterase 2

cGMP-stimulated phosphodiesterase 4

cyclic GMP-stimulated phosphodiesterase

phosphodiesterase 2A, cGMP-stimulated

PDE2A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PDE2A O00408 AIP Homo sapiens O00170
Pull Down
17329248
种属内
PDE2A O00408 AIP Homo sapiens O00170
Confocal
17329248
种属内
PDE2A O00408 AIP Homo sapiens O00170
Anti Bait CoIP
17329248
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PDE2A 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74647 PDE2A Protein, Human (sf9, His) O00408 (E215-H900) ≥95%

关联疾病

疾病名称 别名
Scrotum Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Scrotum

Scrotal Squamous Cell Carcinoma
Transient Global Amnesia

Amnesia, Transient Global
Retinal Degeneration

Degeneration Of Retina
Paroxysmal Dystonia

Paroxysmal Dyskinesia

Pxd - [Paroxysmal Dyskinesia]
Convulsions, Familial Infantile, With Paroxysmal Choreoathetosis

ICCA

Icca Syndrome

Infantile Convulsions And Choreoathetosis

Infantile Convulsions And Paroxysmal Choreoathetosis, Familial

Pkd/Ic

Familial Infantile Convulsions And Paroxysmal Choreoathetosis

Paroxysmal Kinesigenic Dyskinesia With Infantile Convulsions

Convulsions, Infantile, With Paroxysmal Choreoathetosis, Familial

Paroxysmal Kinesigenic Dyskinesia And Infantile Convulsions

Icca Syndrome Paroxysmal Kinesigenic Dyskinesia With Infantile Convulsions

Dyskinetic Syndrome
Paroxysmal Dyskinesia

Paroxysmal Choreoathetosis

Paroxysmal Dystonic Choreoathetosis

Paroxysmal Dyskinesias
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Choreatic Disease

Chorea

Hereditary Chorea
Intellectual Developmental Disorder With Paroxysmal Dyskinesia Or Seizures

IDDPADS
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-111371 PF-05180999 Inhibitor 99.97% Phase 1
HY-103493 TAK-915 Inhibitor 99.74% Phase 1
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-102050 PF-05085727 Inhibitor 99.60% 否
HY-132993 Hcyb1 Inhibitor 98.24% 否
HY-120710 DNS-8254 Inhibitor / 否
HY-142660 PDE2A-IN-1 Inhibitor / 否
HY-RS10213 PDE2A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10214 Pde2a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10215 Pde2a Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-124173 PF-06815189 Inhibitor / 否
HY-112704 PDE5-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PDE2A VGNC VGNC:75912
Canis familiaris PDE2A VGNC VGNC:44351
Felis catus PDE2A VGNC VGNC:68755
Bos taurus PDE2A VGNC VGNC:32674
Mus musculus PDE2A MGD MGI:2446107
Rattus norvegicus PDE2A RGD RGD:620965
Others PDE2A NCBI
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