1. Gene
  2. Rnpep - arginyl aminopeptidase Gene

Rnpep - arginyl aminopeptidase Gene

中文名称:精氨酰氨肽酶

种属: Rattus norvegicus

基因 ID: 81761 | 基因类型: protein coding

关于 Rnpep

Primary_assembly 13: 46,699,463-46,717,998 reverse strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 156 orthologues, 10 paralogues and is associated with 6 phenotypes. Biased expression in Kidney (RPKM 14.6), Testes (RPKM 139.5) and 9 other tissues.

功能概要

该基因编码的蛋白可启动金属氨基肽酶活性;肽结合活性;和过渡金属离子结合活性。涉及多个过程,包括老化;血压的负调节;和相机型眼睛的视网膜发育。位于多种细胞成分中,包括高尔基体;质膜的外侧;和分泌颗粒。用于研究高血压。高血压的生物标志物。与人 RNPEP(精氨酰氨肽酶)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables metalloaminopeptidase activity; peptide binding activity; and transition metal ion binding activity. Involved in several processes, including aging; negative regulation of blood pressure; and retina development in camera-type eye. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and secretory granule. Used to study hypertension. Biomarker of hypertension. Orthologous to human RNPEP (arginyl Aminopeptidase). [provided by Alliance of Genome Resources, Apr 2022]

Rnpep 基因产物(1)

mRNA Protein Name
NM_031097.2 NP_112359.2 aminopeptidase B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aminopeptidase activity IDA
IDA: 通过直接分析推断
8940051 RGD
enables cobalt ion binding IDA
IDA: 通过直接分析推断
17142967 RGD
enables copper ion binding IDA
IDA: 通过直接分析推断
17142967 RGD
enables metalloaminopeptidase activity IDA
IDA: 通过直接分析推断
17142967 RGD
enables peptide binding IDA
IDA: 通过直接分析推断
16537183 RGD
enables zinc ion binding IDA
IDA: 通过直接分析推断
17142967 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of blood pressure IMP
IMP: 通过突变表型推断
3001599 RGD
involved in protein processing IDA
IDA: 通过直接分析推断
16537183 RGD
involved in retina development in camera-type eye IEP
IEP: 通过表达模式推断
15500823 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
9405297 RGD
located in extracellular region IDA
IDA: 通过直接分析推断
9405297 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
16619500 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
9405297 RGD
located in secretory granule IDA
IDA: 通过直接分析推断
15539558 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Rnpep 蛋白结构

M1_LTA4H

M1_LTA4H: cd09599 (23 - 483)

Leuk-A4-hydro_C

Leuk-A4-hydro_C: pfam09127 (529 - 644)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 650 a.a.
蛋白主名 其他名称

aminopeptidase B

AP-B

arginine aminopeptidase

cytosol aminopeptidase IV

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rnpep NCBI NCBI:6051