Tgfbr2 - transforming growth factor, beta receptor 2 Gene

中文名称：转化生长因子， β 受体 2

种属: Rattus norvegicus

同用名: Tgfbr2T; TGF-beta 2

关于 Tgfbr2

功能概要

该基因编码的蛋白可启动丝裂原活化蛋白激酶激酶激酶结合活性和转化生长因子 β 受体活性，II 型。参与多个过程，包括动物器官发育；心肌细胞增殖的负调节；和跨膜受体蛋白丝氨酸/苏氨酸激酶信号通路。位于caveola;细胞表面；和胞质溶胶。是质膜的组成部分。用于研究膜增生性肾小球肾炎。动脉疾病的生物标志物（多种）；肝胆系统癌（多发性）；肾脏疾病;肺纤维化;和 2 型糖尿病。该基因的人类直系同源物与 Loeys-Dietz 综合征 2 相关；马凡综合症；胃肠系统癌症（多发性）；遗传性非息肉病性结直肠癌 6 型；和胰腺癌。与人 TGFBR2（转化生长因子 β 受体 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables mitogen-activated protein kinase kinase kinase binding activity and transforming growth factor beta receptor activity, type II. Involved in several processes, including animal organ development; negative regulation of cardiac muscle cell proliferation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in caveola; cell surface; and cytosol. Is integral component of plasma membrane. Used to study membranoproliferative glomerulonephritis. Biomarker of artery disease (multiple); hepatobiliary system Cancer (multiple); kidney disease; pulmonary fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 2; Marfan syndrome; gastrointestinal system Cancer (multiple); hereditary nonpolyposis colorectal Cancer type 6; and pancreatic Cancer. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2). [provided by Alliance of Genome Resources, Apr 2022]