CAPN2 - calpain 2 Gene

中文名称：钙蛋白酶 2

种属: Homo sapiens

同用名: CANP2; mCANP; CANPL2; CANPml

基因 ID: 824 | 基因类型: protein coding

关于 CAPN2

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:223,701,597-223,776,018 (from NCBI)

This gene has 12 transcripts (splice variants), 246 orthologues and 20 paralogues. Ubiquitous expression in lung (RPKM 90.0), gall bladder (RPKM 66.0) and 25 other tissues.

功能概要

钙蛋白酶是钙激活的中性蛋白酶，是非溶酶体细胞内半胱氨酸蛋白酶。哺乳动物钙蛋白酶包括普遍存在的胃特异性和肌肉特异性蛋白质。无处不在的酶由异二聚体组成，这些异二聚体具有与共同的小调节亚基相关联的独特的大催化亚基。该基因编码普遍存在的酶钙蛋白酶 2 的大亚基。已报道 5' UTR 中的多个异质转录起始位点。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2009 年 3 月]

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous Enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous Enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

CAPN2 基因产物(2)

mRNA	Protein	Name
NM_001146068.2	NP_001139540.1	calpain-2 catalytic subunit isoform 2
NM_001748.5	NP_001739.3	calpain-2 catalytic subunit isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calcium-dependent cysteine-type endopeptidase activity	IDA IDA: 通过直接分析推断	12150984	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10639123	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in proteolysis involved in protein catabolic process	IDA IDA: 通过直接分析推断	12150984	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	14559243	GOA
part of calpain complex	IPI IPI: 通过物理相互作用推断	10639123	GOA
located in cytosol	IDA IDA: 通过直接分析推断	12150984	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	14559243	GOA
colocalizes with membrane raft	IDA IDA: 通过直接分析推断	12150984	GOA
located in membrane raft	IDA IDA: 通过直接分析推断	14559243	GOA
located in perinuclear endoplasmic reticulum	IDA IDA: 通过直接分析推断	14559243	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	12150984	GOA
located in pseudopodium	IDA IDA: 通过直接分析推断	14559243	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CAPN2 蛋白结构

Peptidase_C2

Calpain_III

EF-hand_8

0
200
400
600
700 a.a.

蛋白主名

其他名称

calpain-2 catalytic subunit

CANP 2

CAPN2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CAPN2	P17655	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354
种属内	CAPN2	P17655	CAPNS1	Homo sapiens	P04632	Anti Tag CoIP	33961781
种属内	CAPN2	P17655	CAPNS1	Homo sapiens	P04632	Chromatography	28319173
种属内	CAPN2	P17655	CAPNS1	Homo sapiens	P04632	NMR	18519038
种属内	CAPN2	P17655	LOXL2	Homo sapiens	Q9Y4K0	Anti Bait CoIP	31911079
种属内	CAPN2	P17655	LOXL2	Homo sapiens	Q9Y4K0	Anti Tag CoIP	31911079

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CAPN2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72115	CAPN2 Protein, Human (His)	P17655 (S20-L700)	≥95%

关联疾病

疾病名称

别名

Nuclear Senile Cataract

Senile Nuclear Cataract

Senile Nuclear Sclerosis

Inflammatory Bowel Disease 15

IBD15

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Spinocerebellar Atrophy
Azorean Neurologic Disease	Spinopontine Atrophy
Nigrospinodentatal Degeneration	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Limb-Girdle Muscular Dystrophy

Lgmd	Limb Girdle Muscular Dystrophy
Muscular Dystrophies, Limb-Girdle	Erb'S Muscular Dystrophy
Leyden-Mbius Muscular Dystrophy	Limb-Girdle Syndrome
Myopathic Limb-Girdle Syndrome	Limb Girdle
Muscular Dystrophy Limb-Girdle	Dystrophy, Muscular, Limb-Girdle
Lgmd - [Limb-Girdle Muscular Dystrophy]	Limb Girdle Muscle Dystrophy
Limb-Girdle Myopathy

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Female Stress Incontinence

Female Urinary Stress Incontinence

Stress Incontinence - Female

Marfan Syndrome

MFS	Mfs1
Marfan'S Syndrome	Marfan Syndrome Type 1
Marfan Syndrome, Type I	Mass Phenotype
Contractural Arachnodactyly	Mass Syndrome
Octd	Overlap Connective Tissue Disease
Marfanoid Hypermobility Syndrome	Marfan Disease

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2a

Leyden-Moebius Muscular Dystrophy	Lgmd2a
Limb-Girdle Muscular Dystrophy Due To Calpain Deficiency	Muscular Dystrophy, Limb-Girdle, Type 2a
Pelvofemoral Muscular Dystrophy	Primary Calpainopathy

Wolfram Syndrome 2

WFS2

Diabetic Cataract

Cataract - Diabetic

Muscular Dystrophy, Duchenne Type

Duchenne Muscular Dystrophy	DMD
Muscular Dystrophy, Duchenne	Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type
Severe Dystrophinopathy, Duchenne Type	Muscular Dystrophy Duchenne
Dystrophy, Muscular, Duchenne Type	Benign Duchenne Muscular Dystrophy
Duchenne Motor Neuron Disease	Duchenne Type Dystrophy
Duchenne-Griesinger Disease

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Autosomal Recessive Limb-Girdle Muscular Dystrophy

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01889	CAPN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01896	CAPNS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CAPN2	VGNC	VGNC:60354
Macaca mulatta	CAPN2	VGNC	VGNC:70532
Mus musculus	CAPN2	MGD	MGI:88264
Canis familiaris	CAPN2	VGNC	VGNC:53334
Bos taurus	CAPN2	VGNC	VGNC:55037
Rattus norvegicus	CAPN2	RGD	RGD:2268
Others	CAPN2	NCBI

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