HYAL3 - hyaluronidase 3 Gene

中文名称：透明质酸酶 3

种属: Homo sapiens

同用名: LUCA3; HYAL-3; LUCA-3

关于 HYAL3

功能概要

该基因编码透明质酸酶家族的一个成员。透明质酸酶是降解透明质酸的内切糖苷酶，透明质酸是细胞外基质的主要糖胺聚糖之一。乙酰透明质酸的调节转换在许多生物过程中起着关键作用，包括细胞增殖、迁移和分化。编码的蛋白质也可能在精子功能中发挥重要作用。该基因是染色体 3p21.3 区域中与肿瘤抑制相关的几个相关基因之一，特定转录本变异体的表达可能指示肿瘤状态。已经观察到该基因编码多种亚型的可变剪接转录变体，并且一些亚型可能缺乏透明质酸酶活性。该基因与 N-乙酰转移酶 6 (GCN5 相关) 重叠并位于同一链上，每个基因的一些转录本共享第一个外显子的一部分。[RefSeq 提供，2011 年 1 月]

This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase Enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]