2. Gene
  3. PIP5K1A - phosphatidylinositol-4-phosphate 5-kinase type 1 alpha Gene

PIP5K1A - phosphatidylinositol-4-phosphate 5-kinase type 1 alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷脂酰肌醇 4-磷酸 5-激酶 1 型 α

种属: Homo sapiens

基因 ID: 8394 | 基因类型: protein coding

关于 PIP5K1A

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,195,419-151,249,531 (from NCBI)

This gene has 17 transcripts (splice variants), 239 orthologues and 6 paralogues. Ubiquitous expression in testis (RPKM 22.2), placenta (RPKM 13.0) and 25 other tissues.

功能概要

启用 1-phosphatidylinositol-4-phosphate 5-kinase 活性和激酶结合活性。参与多个过程，包括 GTPase 活性的激活；焦点粘附组件；和荷叶边组装。位于多个细胞成分中，包括 lamellipodium；核斑点；和荷叶边膜。与 mRNA 切割和聚腺苷酸化特异性因子复合物共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and kinase binding activity. Involved in several processes, including activation of GTPase activity; focal adhesion assembly; and ruffle assembly. Located in several cellular components, including lamellipodium; nuclear speck; and ruffle membrane. Colocalizes with mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Apr 2022]

PIP5K1A 基因产物(5)

mRNA Protein Name
NM_001135636.2 NP_001129108.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 3
NM_001135637.2 NP_001129109.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 4
NM_001135638.2 NP_001129110.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 1
NM_001330689.2 NP_001317618.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 5
NM_003557.3 NP_003548.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
IDA: 通过直接分析推断
15157668 GOA
enables kinase binding IDA
IDA: 通过直接分析推断
15157668 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15157668 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IMP
IMP: 通过突变表型推断
20660631 GOA
involved in activation of GTPase activity IMP
IMP: 通过突变表型推断
20660631 GOA
involved in cell chemotaxis IMP
IMP: 通过突变表型推断
20660631 GOA
involved in focal adhesion assembly IMP
IMP: 通过突变表型推断
20660631 GOA
involved in phospholipid biosynthetic process IDA
IDA: 通过直接分析推断
15157668 GOA
involved in protein localization to plasma membrane IMP
IMP: 通过突变表型推断
20660631 GOA
involved in ruffle assembly IMP
IMP: 通过突变表型推断
20660631 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in lamellipodium IDA
IDA: 通过直接分析推断
15157668 GOA
part of mRNA cleavage and polyadenylation specificity factor complex IDA
IDA: 通过直接分析推断
18305108 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
18288197 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15157668 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
20660631 GOA
located in ruffle membrane IDA
IDA: 通过直接分析推断
20660631 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PIP5K1A 蛋白结构

PIP5K

PIP5K: Phosphatidylinositol-4-phosphate 5-Kinase (164 - 448)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 562 a.a.
蛋白主名 其他名称

phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha

PIP5K1A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PIP5K1A Q99755 KRAS Homo sapiens P01116
Pull Down
30194290
种属内
PIP5K1A Q99755 KRAS Homo sapiens P01116
Anti Bait CoIP
30194290
种属内
PIP5K1A Q99755 KRAS Homo sapiens P01116
Anti Tag CoIP
30194290
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10566 PIP5K1A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PIP5K1A VGNC VGNC:55656
Mus musculus PIP5K1A MGD MGI:107929
Macaca mulatta PIP5K1A VGNC VGNC:100037
Felis catus PIP5K1A VGNC VGNC:80303
Rattus norvegicus PIP5K1A RGD RGD:1306127
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