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  2. Prkci - protein kinase C, iota Gene

Prkci - protein kinase C, iota Gene

中文名称:蛋白激酶 C,iota

种属: Rattus norvegicus

同用名: Pkcl

基因 ID: 84006 | 基因类型: protein coding

关于 Prkci

Primary_assembly 2: 112,321,929-112,382,352 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 228 orthologues, 9 paralogues and is associated with 8 phenotypes. Biased expression in Lung (RPKM 259.4), Kidney (RPKM 161.9) and 9 other tissues.

功能概要

预测该基因编码的蛋白可启动磷脂结合活性和蛋白激酶 C 活性。参与多个过程,包括高尔基体小泡出芽;细胞对胰岛素刺激的反应;和对白细胞介素-1 的反应。位于电池前沿;胞质溶胶;和质膜。活跃于 Schaffer 侧支 - CA1 突触和谷氨酸能突触。与双细胞紧密连接共定位。与人 PRKCI(蛋白激酶 C iota)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable phospholipid binding activity and protein kinase C activity. Involved in several processes, including Golgi vesicle budding; cellular response to Insulin stimulus; and response to interleukin-1. Located in cell leading edge; cytosol; and plasma membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Colocalizes with bicellular tight junction. Orthologous to human PRKCI (protein kinase C iota). [provided by Alliance of Genome Resources, Apr 2022]

Prkci 基因产物(1)

mRNA Protein Name
NM_032059.1 NP_114448.1 protein kinase C iota type
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19885391 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse EXP
EXP: 通过实验结果推断
23511975 RGD
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
23511975 RGD
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
23511975 RGD
located in bicellular tight junction IDA
IDA: 通过直接分析推断
9763423 RGD
located in cell leading edge IDA
IDA: 通过直接分析推断
19885391 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
23511975 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
23511975 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
23511975 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Prkci 蛋白结构

PB1_aPKC

PB1_aPKC: cd06404 (25 - 107)

C1_aPKC

C1_aPKC: cd20794 (138 - 192)

STKc_aPKC_iota

STKc_aPKC_iota: cd05618 (232 - 595)

  • 0
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  • 596 a.a.
蛋白主名 其他名称

protein kinase C iota type

aPKC-lambda/iota

atypical protein kinase C-lambda/iota

nPKC-iota

protein kinase C, lambda

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prkci NCBI NCBI:5584