2. Gene
  3. TAGLN2 - transgelin 2 Gene

TAGLN2 - transgelin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：转运蛋白 2

种属: Homo sapiens

同用名: HA1756

基因 ID: 8407 | 基因类型: protein coding

关于 TAGLN2

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:159,918,111-159,925,507 (from NCBI)

This gene has 5 transcripts (splice variants), 150 orthologues and 5 paralogues. Ubiquitous expression in lung (RPKM 268.8), stomach (RPKM 231.0) and 25 other tissues.

功能概要

该基因编码的蛋白质类似于 transgelin 蛋白，是最早分化的平滑肌标志物之一。这种蛋白质的具体功能尚未确定，尽管它被认为是一种肿瘤抑制因子。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2013 年 3 月]

The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

TAGLN2 基因产物(3)

mRNA Protein Name
NM_001277223.2 NP_001264152.1 transgelin-2 isoform b
NM_001277224.2 NP_001264153.1 transgelin-2 isoform a
NM_003564.3 NP_003555.1 transgelin-2 isoform b
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21577206 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in epithelial cell differentiation IDA
IDA: 通过直接分析推断
21492153 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TAGLN2 蛋白结构

CH

CH: Calponin homology (CH) domain (27 - 133)

Calponin

Calponin: Calponin family repeat (174 - 198)

  • 0
  • 100
  • 199 a.a.
蛋白主名 其他名称

transgelin-2

SM22-alpha homolog

TAGLN2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TAGLN2 P37802 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
种属内
TAGLN2 P37802 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
种属内
TAGLN2 P37802 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
种属内
TAGLN2 P37802 TAGLN3 Homo sapiens Q9UI15
Anti Tag CoIP
33961781
种属内
TAGLN2 P37802 TAGLN3 Homo sapiens Q9UI15
Anti Tag CoIP
28514442
种属内
TAGLN2 P37802 ACTB Homo sapiens P60709
Anti Tag CoIP
21577206
种属内
TAGLN2 P37802 SMN1 Homo sapiens Q16637
Validated Y2H
32814053
种属内
TAGLN2 P37802 SMN1 Homo sapiens Q16637
Y2H Array
32814053
种属内
TAGLN2 P37802 SMN1 Homo sapiens Q16637
Y2H Pooling
32814053
种属内
TAGLN2 P37802 HTT Homo sapiens P42858
Validated Y2H
32814053
种属内
TAGLN2 P37802 HTT Homo sapiens P42858
Y2H Array
32814053
种属内
TAGLN2 P37802 HTT Homo sapiens P42858
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Barrett'S Adenocarcinoma

Barrett Adenocarcinoma

Adenocarcinoma Arising In Barrett'S Mucosa
Maxillary Sinus Cancer

Malignant Neoplasm Of Antrum

Malignant Tumor Of The Maxillary Sinus

Maxillary Sinus Carcinoma

Cancer Of Maxillary Sinus

Maxillary Sinus Neoplasms
Maxillary Sinus Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Maxillofacial Sinus
Esophagus Adenocarcinoma

Esophageal Adenocarcinoma

Oesophageal Adenocarcinoma

Adenocarcinoma Of Esophagus

Adenocarcinoma Of The Esophagus
Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14187 TAGLN2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus TAGLN2 VGNC VGNC:65944
Canis familiaris TAGLN2 VGNC VGNC:47094
Mus musculus TAGLN2 MGD MGI:1312985
Bos taurus TAGLN2 VGNC VGNC:35586
Rattus norvegicus TAGLN2 RGD RGD:1310840
Others TAGLN2 NCBI
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