2. Gene
  3. USP44 - ubiquitin specific peptidase 44 Gene

USP44 - ubiquitin specific peptidase 44 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素特异性肽酶 44

种属: Homo sapiens

基因 ID: 84101 | 基因类型: protein coding

关于 USP44

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:95,516,560-95,551,681 (from NCBI)

This gene has 8 transcripts (splice variants), 198 orthologues, 71 paralogues and is associated with 61 phenotypes. Biased expression in testis (RPKM 9.0), lung (RPKM 1.3) and 1 other tissue.

功能概要

该基因编码的蛋白质是一种蛋白酶，具有去泛素化酶的功能。编码的蛋白质被认为通过防止早期后期开始来帮助调节纺锤体组装检查点。这种蛋白质特异性去泛素化 CDC20，从而稳定后期促进复合物/细胞周期体。[RefSeq 提供，2016 年 12 月]

The protein encoded by this gene is a Protease that functions as a deubiquitinating Enzyme. The encoded protein is thought to help regulate the spindle assembly checkpoint by preventing early anaphase onset. This protein specifically deubiquitinates CDC20, which stabilizes the anaphase promoting complex/cyclosome. [provided by RefSeq, Dec 2016]

USP44 基因产物(5)

mRNA Protein Name
NM_001042403.3 NP_001035862.1 ubiquitin carboxyl-terminal hydrolase 44
NM_001278393.2 NP_001265322.1 ubiquitin carboxyl-terminal hydrolase 44
NM_001347936.2 NP_001334865.1 ubiquitin carboxyl-terminal hydrolase 44
NM_001347937.2 NP_001334866.1 ubiquitin carboxyl-terminal hydrolase 44
NM_032147.5 NP_115523.2 ubiquitin carboxyl-terminal hydrolase 44
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type deubiquitinase activity IDA
IDA: 通过直接分析推断
14715245 GOA
enables cysteine-type deubiquitinase activity IMP
IMP: 通过突变表型推断
17443180 GOA
enables deubiquitinase activity IDA
IDA: 通过直接分析推断
17443180 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17443180 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antiviral innate immune response IDA
IDA: 通过直接分析推断
31968013 GOA
involved in negative regulation of mitotic metaphase/anaphase transition IDA
IDA: 通过直接分析推断
17443180 GOA
involved in negative regulation of ubiquitin protein ligase activity IMP
IMP: 通过突变表型推断
17443180 GOA
involved in protein deubiquitination IDA
IDA: 通过直接分析推断
17443180 GOA
involved in regulatory T cell differentiation IDA
IDA: 通过直接分析推断
32644293 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in nucleus IDA
IDA: 通过直接分析推断
32644293 GOA
located in nucleus IDA
IDA: 通过直接分析推断
20402667 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

USP44 蛋白结构

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (29 - 90)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (272 - 675)

  • 0
  • 200
  • 400
  • 600
  • 712 a.a.
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase 44

deubiquitinating enzyme 44

关联疾病

疾病名称 别名
Embryonal Carcinoma

Embryonal Neoplasm

Embryonal Cancer

Primary Extragonadal Embryonal Carcinoma

Embryo Neoplasm

Carcinoma Embryonal

Cancer Embryonal

Carcinoma, Embryonal

Extragonadal Embryonal Carcinoma

Cancer, Embryonal
T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Lissencephaly

Pachygyria

Broad Gyri Of Cerebrum

Large Gyri Of Cerebrum

Macrogyria
Strabismus

Strabismus, Susceptibility To

Strabismus, Susceptibility To, 1

Strabismus 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15555 USP44 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus USP44 VGNC VGNC:66887
Bos taurus USP44 VGNC VGNC:36731
Macaca mulatta USP44 VGNC VGNC:79221
Mus musculus USP44 MGD MGI:3045318
Canis familiaris USP44 VGNC VGNC:48197
Rattus norvegicus USP44 RGD RGD:1308216
Others USP44 NCBI
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