1. Gene
  2. CAMKK1 - calcium/calmodulin dependent protein kinase kinase 1 Gene

CAMKK1 - calcium/calmodulin dependent protein kinase kinase 1 Gene

中文名称:钙/钙调蛋白依赖性蛋白激酶激酶 1

种属: Homo sapiens

同用名: CAMKKA

基因 ID: 84254 | 基因类型: protein coding

关于 CAMKK1

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:3,860,315-3,893,053 (from NCBI)

This gene has 4 transcripts (splice variants), 268 orthologues and 22 paralogues. Broad expression in brain (RPKM 12.8), salivary gland (RPKM 4.6) and 24 other tissues.

功能概要

该基因的产物属于丝氨酸/苏氨酸蛋白激酶家族,以及 CA (2+) /钙调蛋白依赖性蛋白激酶亚家族。这种蛋白质在钙/钙调蛋白依赖性 (CaM) 激酶级联中起作用。已经为该基因鉴定了编码两种不同亚型的三种转录物变体。[RefSeq 提供,2008 年 7 月]

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the CA(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

CAMKK1 基因产物(3)

mRNA Protein Name
NM_032294.3 NP_115670.1 calcium/calmodulin-dependent protein kinase kinase 1 isoform a
NM_172206.2 NP_757343.2 calcium/calmodulin-dependent protein kinase kinase 1 isoform c
NM_172207.3 NP_757344.2 calcium/calmodulin-dependent protein kinase kinase 1 isoform b
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18242179 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CAMKK1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (128 - 409)

  • 0
  • 100
  • 200
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  • 400
  • 505 a.a.
蛋白主名 其他名称

calcium/calmodulin-dependent protein kinase kinase 1

CAMKK alpha protein

CAMKK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CAMKK1 Q8N5S9 YWHAH Homo sapiens Q04917 32707033
种属内
CAMKK1 Q8N5S9 YWHAE Homo sapiens P62258 32707033
种属内
CAMKK1 Q8N5S9 YWHAE Homo sapiens P62258 36931259
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Tracheitis

Acute Tracheitis

Chronic Tracheitis

Bacterial Tracheitis

Acute Tracheitis Nos

Tracheitis Nos

Tracheal Inflammation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CAMKK1 VGNC VGNC:60336
Bos taurus CAMKK1 VGNC VGNC:26725
Rattus norvegicus CAMKK1 RGD RGD:62023
Mus musculus CAMKK1 MGD MGI:1891766
Canis familiaris CAMKK1 VGNC VGNC:38683
Macaca mulatta CAMKK1 VGNC VGNC:99125
Others CAMKK1 NCBI