2. Gene
  3. DYRK3 - dual specificity tyrosine phosphorylation regulated kinase 3 Gene

DYRK3 - dual specificity tyrosine phosphorylation regulated kinase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：双特异性酪氨酸磷酸化调节激酶 3

种属: Homo sapiens

同用名: RED; REDK; DYRK5; hYAK3-2

基因 ID: 8444 | 基因类型: protein coding

关于 DYRK3

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,635,536-206,655,158 (from NCBI)

This gene has 6 transcripts (splice variants), 201 orthologues and 12 paralogues. Broad expression in testis (RPKM 8.5), gall bladder (RPKM 5.7) and 19 other tissues.

功能概要

该基因产物属于双特异性蛋白激酶 DYRK 家族，可催化丝氨酸/苏氨酸和酪氨酸残基的自磷酸化。该家族的成员结构相似，但底物特异性不同，表明它们参与不同的细胞功能。编码的蛋白质已显示在酪氨酸残基上自磷酸化并在体外催化组蛋白 H3 和 H2B 的磷酸化。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

DYRK3 基因产物(7)

mRNA Protein Name
XM_047432114.1 XP_047288070.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1
NM_001004023.3 NP_001004023.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b
XM_047432115.1 XP_047288071.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1
XM_047432118.1 XP_047288074.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X2
XM_011510061.3 XP_011508363.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X2
NM_003582.4 NP_003573.2 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform a
XM_005273315.5 XP_005273372.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
10779429 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
10779429 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
10779429 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
29634919 GOA
enables protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
23415227 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in erythrocyte differentiation IDA
IDA: 通过直接分析推断
10779429 GOA
involved in nuclear speck organization IDA
IDA: 通过直接分析推断
29973724 GOA
involved in organelle disassembly IDA
IDA: 通过直接分析推断
29973724 GOA
involved in positive regulation of cell cycle G2/M phase transition IDA
IDA: 通过直接分析推断
29973724 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
10779429 GOA
involved in regulation of TORC1 signaling IMP
IMP: 通过突变表型推断
23415227 GOA
involved in regulation of cellular response to stress IMP
IMP: 通过突变表型推断
23415227 GOA
involved in stress granule disassembly IDA
IDA: 通过直接分析推断
29973724 GOA
involved in stress granule disassembly IMP
IMP: 通过突变表型推断
23415227 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
23415227 GOA
located in cytoplasmic stress granule IDA
IDA: 通过直接分析推断
23415227 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
29973724 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10779429 GOA
located in pericentriolar material IDA
IDA: 通过直接分析推断
29973724 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DYRK3 蛋白结构

Pkinase

Pkinase: Protein kinase domain (209 - 522)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 588 a.a.
蛋白主名 其他名称

dual specificity tyrosine-phosphorylation-regulated kinase 3

dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5

protein kinase Dyrk3

regulatory erythroid kinase

重组 DYRK3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76308 DYRK3 Protein, Human (sf9, His-GST) O43781 (M1-S588) ≥95%

关联疾病

疾病名称 别名
Neuroaspergillosis
Intellectual Developmental Disorder, Autosomal Dominant 7

MRD7

Mental Retardation, Autosomal Dominant 7

Autosomal Dominant Non-Syndromic Intellectual Disability 7

Dyrk1a Syndrome

Autosomal Dominant Intellectual Developmental Disorder 7

Autosomal Dominant Mental Retardation 7

Mental Retardation, Autosomal Dominant, Type 7
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-105309 GSK-626616 Inhibitor 99.77% 否
HY-162750 ZJCK-6-46 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DYRK3 RGD RGD:1310924
Canis familiaris DYRK3 VGNC VGNC:40158
Mus musculus DYRK3 MGD MGI:1330300
Macaca mulatta DYRK3 VGNC VGNC:72020
Bos taurus DYRK3 VGNC VGNC:28281
Felis catus DYRK3 VGNC VGNC:61688
Others DYRK3 NCBI
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