2. Gene
  3. RAB11FIP4 - RAB11 family interacting protein 4 Gene

RAB11FIP4 - RAB11 family interacting protein 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RAB11 家族相互作用蛋白 4

种属: Homo sapiens

同用名: FIP4-Rab11; RAB11-FIP4

基因 ID: 84440 | 基因类型: protein coding

关于 RAB11FIP4

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:31,391,675-31,538,211 (from NCBI)

This gene has 11 transcripts (splice variants), 283 orthologues and 1 paralogue. Broad expression in brain (RPKM 25.4), testis (RPKM 6.0) and 17 other tissues.

功能概要

由该基因编码的蛋白质与 RAB11 相互作用，被认为参与了在胞质分裂晚期将回收的内体膜带到卵裂沟。缺氧条件可导致编码蛋白的上调并增强肝细胞癌的转移潜能。[RefSeq 提供，2016 年 10 月]

The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]

RAB11FIP4 基因产物(5)

mRNA Protein Name
NM_001303542.3 NP_001290471.2 rab11 family-interacting protein 4 isoform 2
NM_001346747.2 NP_001333676.1 rab11 family-interacting protein 4 isoform 3
NM_001346748.2 NP_001333677.1 rab11 family-interacting protein 4 isoform 4
NM_001346749.2 NP_001333678.1 rab11 family-interacting protein 4 isoform 5
NM_032932.6 NP_116321.2 rab11 family-interacting protein 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12470645 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
12470645 GOA
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
12470645 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of cytokinesis IMP
IMP: 通过突变表型推断
16148947 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cleavage furrow IDA
IDA: 通过直接分析推断
15601896 GOA
located in endocytic vesicle IDA
IDA: 通过直接分析推断
20682791 GOA
located in endosome IDA
IDA: 通过直接分析推断
20682791 GOA
located in midbody IDA
IDA: 通过直接分析推断
15601896 GOA
located in recycling endosome membrane IDA
IDA: 通过直接分析推断
12470645 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAB11FIP4 蛋白结构

RBD-FIP

RBD-FIP: FIP domain (596 - 636)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 637 a.a.
蛋白主名 其他名称

rab11 family-interacting protein 4

RAB11 family interacting protein 4 (class II)

关联疾病

疾病名称 别名
Chromosome 17q11.2 Deletion Syndrome

Nf1 Microdeletion Syndrome

17q11 Microdeletion Syndrome

Neurofibromatosis Type 1 Microdeletion Syndrome

Van Asperen Syndrome

Del(17)(Q11)

Monosomy 17q11

Chromosome 17q11.2 Deletion Syndrome, 1.4mb
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11519 RAB11FIP4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus RAB11FIP4 VGNC VGNC:64470
Bos taurus RAB11FIP4 VGNC VGNC:33619
Mus musculus RAB11FIP4 MGD MGI:2442920
Macaca mulatta RAB11FIP4 VGNC VGNC:76571
Canis familiaris RAB11FIP4 VGNC VGNC:45251
Rattus norvegicus RAB11FIP4 RGD RGD:1305063
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