TUBB6 - tubulin beta 6 class V Gene

中文名称：微管蛋白 6 V 类

种属: Homo sapiens

同用名: FPVEPD; TUBB-5; HsT1601

基因 ID: 84617 | 基因类型: protein coding

关于 TUBB6

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:12,307,669-12,329,826 (from NCBI)

This gene has 14 transcripts (splice variants), 140 orthologues, 23 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 41.4), esophagus (RPKM 38.3) and 25 other tissues.

功能概要

预计启用 GTP 绑定活动。预计是细胞骨架的结构成分。预计参与微管细胞骨架组织和有丝分裂细胞周期。位于微管中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable GTP binding activity. Predicted to be a structural constituent of Cytoskeleton. Predicted to be involved in microtubule Cytoskeleton organization and mitotic cell cycle. Located in microtubule. [provided by Alliance of Genome Resources, Apr 2022]

TUBB6 基因产物(8)

mRNA	Protein	Name
NM_001303524.1	NP_001290453.1	tubulin beta-6 chain isoform 1
NM_001303525.2	NP_001290454.1	tubulin beta-6 chain isoform 2
NM_001303526.2	NP_001290455.1	tubulin beta-6 chain isoform 3
NM_001303527.2	NP_001290456.1	tubulin beta-6 chain isoform 4
NM_001303528.2	NP_001290457.1	tubulin beta-6 chain isoform 5
NM_001303529.3	NP_001290458.1	tubulin beta-6 chain isoform 6
NM_001303530.3	NP_001290459.1	tubulin beta-6 chain isoform 6
NM_032525.3	NP_115914.1	tubulin beta-6 chain isoform 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	24275654	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in microtubule	IDA IDA: 通过直接分析推断	21525035	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TUBB6 蛋白结构

Tubulin

Tubulin_C

0
100
200
300
400
446 a.a.

蛋白主名

其他名称

tubulin beta-6 chain

class V beta-tubulin

TUBB6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TUBB6	Q9BUF5	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
种属内	TUBB6	Q9BUF5	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
种属内	TUBB6	Q9BUF5	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
种属内	TUBB6	Q9BUF5	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
种属内	TUBB6	Q9BUF5	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
种属内	TUBB6	Q9BUF5	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
种属内	TUBB6	Q9BUF5	LRRK2	Homo sapiens	Q5S007	Y2H	24275654
种属内	TUBB6	Q9BUF5	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
种属内	TUBB6	Q9BUF5	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
种属内	TUBB6	Q9BUF5	WFS1	Homo sapiens	O76024	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Facial Palsy, Congenital, With Ptosis And Velopharyngeal Dysfunction

FPVEPD

3-Methylglutaconic Aciduria, Type Iii

Optic Atrophy	3-Methylglutaconic Aciduria Type 3
Costeff Syndrome	Mga3
Costeff Optic Atrophy Syndrome	Optic Atrophy Plus Syndrome
Infantile Optic Atrophy With Chorea And Spastic Paraplegia	3-Methylglutaconic Aciduria Type Iii
Autosomal Recessive Optic Atrophy Plus Syndrome	Autosomal Recessive Optic Atrophy Type 3
Opa3 Defect	MGCA3
Mga, Type Iii	Iraqi Jewish Optic Atrophy Plus
Mga Type Iii	Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia
Iraqi-Jewish 'Optic Atrophy Plus'	Optic Atrophy 3, Autosomal Recessive
Opa3, Autosomal Recessive	Opa3-Related 3-Methylglutaconic Aciduria
Iraqi-Jewish Optic Atrophy Plus	Atrophy Of Optic Disc
3-Alpha Methylglutaconic Aciduria Type Iii	Optic Atrophy 3
Optic Atrophy Infantile With Chorea And Spastic Paraplegia	Autosomal Recessive Opa3
Autosomal Recessive Optic Atrophy 3	3-Methylglutaconic Aciduria 3
3-Alpha-Methylglutaconic Aciduria Type 3	Optic Atrophy 3 Autosomal Recessive
Atrophy, Optic	Atrophy, Optic, Plus Syndrome
Optic Nerve Atrophy	Primary Optic Atrophy
Oa - [Optic Atrophy]	Second Cranial Nerve Atrophy
Second Cranium Nerve Atrophy

Tubulin, Beta

Ptosis

Blepharoptosis	Drooping Eyelid
Droopy Eyelid	Ptosis Of Eyelid
Paralysis Of Levator Palpebrae Superioris

Tubulinopathy

Tubulinopathies

Multiple Benign Circumferential Skin Creases On Limbs

Ccsf	Circumferential Skin Creases, Kunze Type
Congenital Circumferential Skin Folds	Kunze-Riehm Syndrome
Kunze Riehm Syndrome	Michelin Tire Baby Syndrome

Microlissencephaly

Nail Disorder, Nonsyndromic Congenital, 4

Anonychia Congenita	Anonychia
Hyponychia Congenita	NDNC4
Anonychia/Hyponychia Congenita	Nonsyndromic Congenital Nail Disorder 4
Isolated Congenital Anonychia	Anonychia Congenita Totalis
Anonychia Totalis	Autosomal Recessive Nonsyndromic Congenital Nail Disorder-4
Congenital Anonychia	Nonsyndromic Congenital Nail Disorder, 4
Absent Nails	Aplastic Nails
Congenital Absence Of Nails	Isolated Anonychia
Nail Disorder, Non-Syndromic Congenital, 4	Nail Disorder, Nonsyndromic, Congenital, Type 4

Congenital Fibrosis Of The Extraocular Muscles

Congenital Fibrosis Of Extraocular Muscles	Cfeom
Feom	Congenital External Ophthalmoplegia
Congenital Fibrosis Syndrome	General Fibrosis Syndrome

Nonsyndromic Congenital Nail Disorder

Nail Disorder, Nonsyndromic Congenital

Congenital Ptosis

Congenital Blepharoptosis

Congenital Eyelid Ptosis

Bardet-Biedl Syndrome 1

BBS1	Bardet-Biedl Syndrome 1, Modifier Of
Bardet-Biedl Syndrome	BBS
Bardet-Biedl Syndrome, Type 1	Laurence-Moon-Bardet-Biedl Syndrome

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15257	TUBB6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	TUBB6	VGNC	VGNC:104253
Felis catus	TUBB6	VGNC	VGNC:80542
Canis familiaris	TUBB6	VGNC	VGNC:47991
Rattus norvegicus	TUBB6	RGD	RGD:1305887
Bos taurus	TUBB6	VGNC	VGNC:36509
Mus musculus	TUBB6	MGD	MGI:1915201

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TUBB6 - tubulin beta 6 class V Gene

关于 TUBB6

功能概要

TUBB6 基因产物(8)

TUBB6 蛋白结构

TUBB6 蛋白互作信息

关联疾病

直系同源

热门区域

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TUBB6 - tubulin beta 6 class V Gene

关于 TUBB6

功能概要

TUBB6 基因产物(8)

TUBB6 蛋白结构

TUBB6 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z