CBX2 - chromobox 2 Gene

中文名称：色盒 2

种属: Homo sapiens

同用名: M33; CDCA6; SRXY5

基因 ID: 84733 | 基因类型: protein coding

关于 CBX2

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:79,777,311-79,787,983 (from NCBI)

This gene has 3 transcripts (splice variants), 251 orthologues, 8 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 5.1), placenta (RPKM 1.0) and 13 other tissues.

功能概要

该基因编码 polycomb 多蛋白复合物的一个成分，它需要通过染色质重塑和组蛋白修饰在整个发育过程中维持许多基因的转录抑制状态。在小鼠中破坏该基因会导致雄性到雌性的性腺性逆转。该基因的突变也与人类性腺发育不全有关。已注意到该基因编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2010 年 3 月]

This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2010]

CBX2 基因产物(2)

mRNA	Protein	Name
NM_005189.3	NP_005180.1	chromobox protein homolog 2 isoform 1
NM_032647.4	NP_116036.1	chromobox protein homolog 2 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in development of primary sexual characteristics	IMP IMP: 通过突变表型推断	19361780	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	21282530	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of PRC1 complex	IDA IDA: 通过直接分析推断	12167701	GOA
part of PcG protein complex	IDA IDA: 通过直接分析推断	21282530	GOA
located in nucleus	IDA IDA: 通过直接分析推断	21282530	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CBX2 蛋白结构

Chromo

0
100
200
300
400
500
532 a.a.

蛋白主名

其他名称

chromobox protein homolog 2

Pc class homolog

CBX2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CBX2	Q14781	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	25416956
种属内	CBX2	Q14781	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	25416956
种属内	CBX2	Q14781	KRTAP2-3	Homo sapiens	P0C7H8	Validated Y2H	25416956
种属内	CBX2	Q14781	DHX57	Homo sapiens	Q6P158	Validated Y2H	25416956
种属内	CBX2	Q14781	MDFI	Homo sapiens	Q99750	Y2H Pooling	19060904
种属内	CBX2	Q14781	MDFI	Homo sapiens	Q99750	Y2H Array	19060904
种属内	CBX2	Q14781	RBMY1A1	Homo sapiens	P0DJD3	Validated Y2H	25416956
种属内	CBX2	Q14781	RBMY1F	Homo sapiens	Q15415	Y2H Array	25416956
种属内	CBX2	Q14781	RBMY1F	Homo sapiens	Q15415	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

CBX2 抗体

目录号	产品名	应用	反应物种
HY-P82678	CBX2 Antibody (YA2423)	WB, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

46,Xy Sex Reversal 5

SRXY5	46,Xy Sex Reversal, Cbx2-Related
46,Xy Gonadal Dysgenesis, Complete, Cbx2-Related	Sex Reversal, Xy, Cbx2-Related
Disorder Of Sex Development, 46,Xy, Cbx2-Related	46xy Sex Reversal 5
46,Xy Gonadal Dysgenesis Complete Cbx2-Related	46,Xy Sex Reversal Cbx2-Related
Disorder Of Sex Development 46,Xy Cbx2-Related	Sex Reversal Xy Cbx2-Related
46, Xy Sex Reversal 5

46,Xy Sex Reversal

Swyer Syndrome	Pure Gonadal Dysgenesis 46,Xy
Gonadal Dysgenesis, Xy Female Type	Gonadal Dysgenesis, 46,Xy
46,Xy Cgd	46,Xy Complete Gonadal Dysgenesis
46,Xy Pure Gonadal Dysgenesis	46 Xy Gonadal Dysgenesis
46, Xy Cgd	46, Xy Complete Gonadal Dysgenesis
46, Xy Pure Gonadal Dysgenesis	Xy Pure Gonadal Dysgenesis
Female With 46,Xy Karyotype	Xy Females

Gonadal Dysgenesis

Gonadal Dysgenesis Syndrome

Turner Syndrome

Disorder Of Sexual Development

Disorder Of Sex Development	Disorders Of Sex Development
Sex Development Disorder	Sex Differentiation Disease
Dsd	Sex Differentiation Disorders

Pontocerebellar Hypoplasia, Type 13

PCH13	Pontocerebellar Hypoplasia Type 13
Pontocerebellar Hypoplasia 13	Doid:0112332
Hypoplasia, Pontocerebellar, Type 13

Primary Hyperoxaluria

Hyperoxaluria	Hyperoxaluria, Primary
Oxalosis	Primary Oxalosis
Congenital Oxaluria	D-Glycerate Dehydrogenase Deficiency
Glyceric Aciduria	Glycolic Aciduria
Hepatic Agt Deficiency	Oxaluria, Primary
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Primary Oxaluria
Hyperoxaluria Primary	Primary Hyperoxaluria Type 2
Primary Hyperoxaluria, Type I

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-147058	SW2_152F	Inhibitor	99.77%	否
HY-RS02009	CBX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CBX2	MGD	MGI:88289
Bos taurus	CBX2	VGNC	VGNC:26817
Felis catus	CBX2	VGNC	VGNC:98769
Canis familiaris	CBX2	VGNC	VGNC:51933
Macaca mulatta	CBX2	VGNC	VGNC:99127
Rattus norvegicus	CBX2	RGD	RGD:1588561
Others	CBX2	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CBX2 - chromobox 2 Gene

关于 CBX2

功能概要

CBX2 基因产物(2)

CBX2 蛋白结构

CBX2 蛋白互作信息

CBX2 抗体

关联疾病

直系同源

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CBX2 - chromobox 2 Gene

关于 CBX2

功能概要

CBX2 基因产物(2)

CBX2 蛋白结构

CBX2 蛋白互作信息

CBX2 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z