HIRIP3 - HIRA interacting protein 3 Gene

中文名称：HIRA 相互作用蛋白 3

种属: Homo sapiens

关于 HIRIP3

功能概要

HIRA 蛋白与 Hir1p 和 Hir2p 具有序列相似性，Hir1p 和 Hir2p 是酵母、酿酒酵母中表征的组蛋白基因转录的两个辅阻遏物。 HIRA 蛋白的结构特征表明它可能作为多蛋白复合物的一部分起作用。已经鉴定出几种编码 HIRA 相互作用蛋白或 HIRIP 的 cDNA。在体外，该基因编码的蛋白质结合 HIRA 以及 H2B 和 H3 核心组蛋白，表明含有 HIRA-HIRIP3 的复合物可以在染色质和组蛋白代谢的某些方面发挥作用。已为该基因发现编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 8 月]

The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011]