1. Gene
  2. ZNF503 - zinc finger protein 503 Gene

ZNF503 - zinc finger protein 503 Gene

中文名称:锌指蛋白 503

种属: Homo sapiens

同用名: Nlz2; NOLZ1; NOLZ-1

基因 ID: 84858 | 基因类型: protein coding

关于 ZNF503

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:75,279,725-75,401,916 (from NCBI)

This gene has 1 transcript (splice variant), 262 orthologues and 1 paralogue. Broad expression in kidney (RPKM 5.4), prostate (RPKM 1.9) and 14 other tissues.

功能概要

预测可启用金属离子结合活性。参与 G1 到 G0 的转变,参与细胞分化;细胞群增殖的负调节;和基因表达的负调控。预计活跃于核心。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable metal ion binding activity. Involved in G1 to G0 transition involved in cell differentiation; negative regulation of cell population proliferation; and negative regulation of gene expression. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF503 基因产物(1)

mRNA Protein Name
NM_032772.6 NP_116161.2 zinc finger protein 503
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G1 to G0 transition involved in cell differentiation IDA
IDA: 通过直接分析推断
20735826 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
20735826 GOA
involved in negative regulation of gene expression IDA
IDA: 通过直接分析推断
20735826 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ZNF503 蛋白结构

nlz1

nlz1: NocA-like zinc-finger protein 1 (233 - 274)

nlz1

nlz1: NocA-like zinc-finger protein 1 (355 - 415)

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  • 646 a.a.
蛋白主名 其他名称

zinc finger protein 503

ZNF503 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ZNF503 Q96F45 ATN1 Homo sapiens Q86V38
Y2H Array
32296183
Intra ZNF503 Q96F45 ATN1 Homo sapiens Q86V38
Y2H Prey Pooling
32296183
Intra ZNF503 Q96F45 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra ZNF503 Q96F45 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra ZNF503 Q96F45 KRTAP19-1 Homo sapiens Q8IUB9
Y2H Prey Pooling
32296183
Intra ZNF503 Q96F45 KRTAP19-1 Homo sapiens Q8IUB9
Y2H Array
32296183
Cross ZNF503 Q96F45 P0DTD1-PRO_0000449627 SARS-CoV-2 P0DTD1-PRO_0000449627
Y2H Array
36217030
Intra ZNF503 Q96F45 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra ZNF503 Q96F45 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
Intra ZNF503 Q96F45 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra ZNF503 Q96F45 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
Intra ZNF503 Q96F45 ARID5A Homo sapiens Q03989
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Fanconi Anemia, Complementation Group B

Fanconi Anemia Complementation Group B

FANCB

Facb

Fa2

Fanconi Pancytopenia Type 2

Fanconi Pancytopenia, Type 2

Coloboma Of Macula

Coloboma

Congenital Ocular Coloboma

Microphthalmia, Isolated, With Coloboma

Agenesis Of Macula

Hereditary Macular Coloboma

Ocular Coloboma

Coloboma Of Eye

Macular Coloboma

Uveoretinal Coloboma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ZNF503 RGD RGD:1312018
Macaca mulatta ZNF503 VGNC VGNC:79398
Bos taurus ZNF503 VGNC VGNC:37288
Mus musculus ZNF503 MGD MGI:1353644
Felis catus ZNF503 VGNC VGNC:67313
Canis familiaris ZNF503 VGNC VGNC:48741