2. Gene
  3. CBR4 - carbonyl reductase 4 Gene

CBR4 - carbonyl reductase 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：羰基还原酶 4

种属: Homo sapiens

同用名: SDR45C1

基因 ID: 84869 | 基因类型: protein coding

关于 CBR4

Cytogenetic location: 4q32.3 Genomic coordinates (GRCh38): 4:168,894,486-169,010,255 (from NCBI)

This gene has 7 transcripts (splice variants) and 194 orthologues. Ubiquitous expression in lung (RPKM 23.4), fat (RPKM 17.8) and 25 other tissues.

功能概要

启用多种功能，包括 3-oxoacyl-[acyl-carrier-protein] 还原酶 (NADPH) 活性； NADPH 结合活性；和 NADPH 脱氢酶 (醌) 活性。参与脂肪酸生物合成过程；糖苷代谢过程；和蛋白质四聚化。位于线粒体基质中。氧化还原酶复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NADPH binding activity; and NADPH dehydrogenase (quinone) activity. Involved in fatty acid biosynthetic process; glycoside metabolic process; and protein tetramerization. Located in mitochondrial matrix. Part of oxidoreductase complex. [provided by Alliance of Genome Resources, Apr 2022]

CBR4 基因产物(1)

mRNA Protein Name
NM_032783.5 NP_116172.2 3-oxoacyl-[acyl-carrier-protein] reductase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IDA
IDA: 通过直接分析推断
19571038 GOA
enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IMP
IMP: 通过突变表型推断
25203508 GOA
enables NAD(P)H dehydrogenase (quinone) activity IDA
IDA: 通过直接分析推断
20837989 GOA
enables NADPH binding IDA
IDA: 通过直接分析推断
19000905 GOA
enables NADPH dehydrogenase (quinone) activity IDA
IDA: 通过直接分析推断
19000905 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19571038 GOA
enables quinone binding IDA
IDA: 通过直接分析推断
19000905 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in daunorubicin metabolic process IMP
IMP: 通过突变表型推断
20837989 GOA
involved in doxorubicin metabolic process IMP
IMP: 通过突变表型推断
20837989 GOA
involved in fatty acid biosynthetic process IMP
IMP: 通过突变表型推断
25203508 GOA
involved in protein heterotetramerization IDA
IDA: 通过直接分析推断
25203508 GOA
involved in protein homotetramerization IDA
IDA: 通过直接分析推断
19000905 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial matrix IDA
IDA: 通过直接分析推断
19000905 GOA
part of oxidoreductase complex IDA
IDA: 通过直接分析推断
19571038 GOA
part of oxidoreductase complex IMP
IMP: 通过突变表型推断
25203508 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CBR4 蛋白结构

adh_short

adh_short: short chain dehydrogenase (3 - 166)

  • 0
  • 100
  • 200
  • 237 a.a.
蛋白主名 其他名称

3-oxoacyl-[acyl-carrier-protein] reductase

3-ketoacyl-[acyl-carrier-protein] reductase beta subunit

关联疾病

疾病名称 别名
Bile Acid Synthesis Defect, Congenital, 5

Congenital Bile Acid Synthesis Defect 5

CBAS5

Bile Acid Synthesis Defect, Congenital, Type 5
Horner'S Syndrome

Horner Syndrome

Bernard-Horner Syndrome

Oculosympathetic Palsy

Bernard Horner Syndrome

Cervical Sympathetic Paralysis

Von Passow Syndrome

Cervical Sympathetic Dystrophy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02006 CBR4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CBR4 VGNC VGNC:26815
Mus musculus CBR4 MGD MGI:2384567
Macaca mulatta CBR4 VGNC VGNC:70635
Canis familiaris CBR4 VGNC VGNC:38765
Rattus norvegicus CBR4 RGD RGD:727826
Felis catus CBR4 VGNC VGNC:60424
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