RAB2B - RAB2B, member RAS oncogene family Gene

中文名称：RAB2B，成员 RAS 致癌基因家族

种属: Homo sapiens

基因 ID: 84932 | 基因类型: protein coding

关于 RAB2B

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,459,020-21,476,959 (from NCBI)

This gene has 6 transcripts (splice variants), 114 orthologues and 68 paralogues. Ubiquitous expression in bone marrow (RPKM 6.9), testis (RPKM 6.8) and 25 other tissues.

功能概要

Rab 蛋白家族的成员是 Ras 超家族的非转化单体 GTP 结合蛋白，包含 4 个参与 GTP 结合和水解的高度保守区域。 Rab 蛋白是异戊二烯化的膜结合蛋白，参与囊泡融合和运输；参见 MIM 179508。[OMIM 提供，2006 年 4 月]

Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM, Apr 2006]

RAB2B 基因产物(2)

mRNA	Protein	Name
NM_001163380.2	NP_001156852.1	ras-related protein Rab-2B isoform 2
NM_032846.4	NP_116235.2	ras-related protein Rab-2B isoform 1

RAB2B 蛋白结构

Ras

0
100
200
216 a.a.

蛋白主名

其他名称

ras-related protein Rab-2B

GTP-binding protein RAB2B

RAB2B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	RAB2B	Q8WUD1	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	25416956
Intra	RAB2B	Q8WUD1	ICA1	Homo sapiens	Q05084	Y2H Array	29892012
Intra	RAB2B	Q8WUD1	GDI2	Homo sapiens	P50395	Anti Tag CoIP	33961781
Intra	RAB2B	Q8WUD1	GDI2	Homo sapiens	P50395	Anti Tag CoIP	35271311
Intra	RAB2B	Q8WUD1	FAM114A2	Homo sapiens	Q9NRY5	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	FAM114A2	Homo sapiens	Q9NRY5	Validated Y2H	32296183
Intra	RAB2B	Q8WUD1	FAM114A2	Homo sapiens	Q9NRY5	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	TBX19	Homo sapiens	O60806	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	TBX19	Homo sapiens	O60806	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	VRTN	Homo sapiens	Q9H8Y1	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	VRTN	Homo sapiens	Q9H8Y1	Validated Y2H	32296183
Intra	RAB2B	Q8WUD1	VRTN	Homo sapiens	Q9H8Y1	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	GARIN1A	Homo sapiens	Q6NXP2-2	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	GARIN1A	Homo sapiens	Q6NXP2-2	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	GARIN4	Homo sapiens	Q8IYT1	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	GARIN4	Homo sapiens	Q8IYT1	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	32296183
Intra	RAB2B	Q8WUD1	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	25416956
Intra	RAB2B	Q8WUD1	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	FAM114A1	Homo sapiens	Q8IWE2	Validated Y2H	25416956
Intra	RAB2B	Q8WUD1	FAM114A1	Homo sapiens	Q8IWE2	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	FAM114A1	Homo sapiens	Q8IWE2	Anti Tag CoIP	33961781
Intra	RAB2B	Q8WUD1	FAM114A1	Homo sapiens	Q8IWE2	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	RAB2B	Q8WUD1	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	RAB2B	Q8WUD1	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	STAMBPL1	Homo sapiens	Q96FJ0	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	STAMBPL1	Homo sapiens	Q96FJ0	Validated Y2H	32296183
Intra	RAB2B	Q8WUD1	STAMBPL1	Homo sapiens	Q96FJ0	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	TXNDC11	Homo sapiens	Q6PKC3	Y2H Array	32296183
Intra	RAB2B	Q8WUD1	TXNDC11	Homo sapiens	Q6PKC3	Y2H Prey Pooling	32296183
Intra	RAB2B	Q8WUD1	GARIN6	Homo sapiens	Q8NEG0	Y2H Array	25416956
Intra	RAB2B	Q8WUD1	GARIN6	Homo sapiens	Q8NEG0	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Carpenter Syndrome 1

Carpenter Syndrome	Acrocephalopolysyndactyly Type Ii
Acps Ii	CRPT1
Acrocephalopolysyndactyly Type 2	Acrocephalosyndactyly, Type Ii
Acrocephalopolysyndactyly 2	Acps2
Acps 2	Type Ii Acrocephalosyndactyly
Carpenter Syndrome, Type 1	Apert-Crouzon Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11542	RAB2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	RAB2B	MGD	MGI:1923588
Macaca mulatta	RAB2B	VGNC	VGNC:81530
Rattus norvegicus	RAB2B	RGD	RGD:1309117
Bos taurus	RAB2B	VGNC	VGNC:33638
Felis catus	RAB2B	VGNC	VGNC:97588
Canis familiaris	RAB2B	VGNC	VGNC:45272

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