2. Gene
  3. Synj1 - synaptojanin 1 Gene

Synj1 - synaptojanin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 85238 | 基因类型: protein coding

关于 Synj1

功能概要

Enables Phosphatase activity; protein C-terminus binding activity; and protein domain specific binding activity. Involved in several processes, including nervous system development; positive regulation of receptor-mediated endocytosis; and response to retinoic acid. Located in cytoplasm; neuron projection; and synaptic membrane. Part of clathrin coat of coated pit. Is active in parallel fiber to Purkinje cell synapse and presynapse. Colocalizes with microtubule. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 20; and developmental and epileptic encephalopathy 53. Orthologous to human SYNJ1 (synaptojanin 1). [provided by Alliance of Genome Resources, Apr 2022]

Synj1 基因产物(1)

mRNA Protein Name
NM_053476.3 NP_445928.2 synaptojanin-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables EH domain binding IDA
IDA: 通过直接分析推断
9428629 RGD
enables SH3 domain binding IDA
IDA: 通过直接分析推断
8552192 RGD
enables SH3 domain binding IPI
IPI: 通过物理相互作用推断
11498538 RGD
enables inositol-1,4,5-trisphosphate 5-phosphatase activity IDA
IDA: 通过直接分析推断
8552192 RGD
enables phosphatidylinositol phosphate 5-phosphatase activity IDA
IDA: 通过直接分析推断
8552192 RGD
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
IDA: 通过直接分析推断
8552192 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9238017 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
17257598 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of gliogenesis IMP
IMP: 通过突变表型推断
19282871 RGD
involved in positive regulation of receptor-mediated endocytosis IMP
IMP: 通过突变表型推断
15821731 RGD
involved in response to cytokine IMP
IMP: 通过突变表型推断
19282871 RGD
involved in response to retinoic acid IMP
IMP: 通过突变表型推断
19282871 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of clathrin coat of coated pit IDA
IDA: 通过直接分析推断
9428629 RGD
located in membrane IDA
IDA: 通过直接分析推断
8798761 RGD
located in microtubule IDA
IDA: 通过直接分析推断
9428629 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: 通过直接分析推断
7982917 RGD
is active in presynapse IDA
IDA: 通过直接分析推断
7982917 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
17257598 RGD
located in synaptic membrane IDA
IDA: 通过直接分析推断
9079704 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

synaptojanin-1

synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1

Synj1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross Synj1 Q62910 MYO1E Homo sapiens Q12965
Pull Down
17257598
Cross Synj1 Q62910 SH3GL2 Homo sapiens Q99962
Pull Down
17257598
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14093 SYNJ1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Synj1 NCBI NCBI:8867
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