2. Gene
  3. CST7 - cystatin F Gene

CST7 - cystatin F Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胱抑素 F

种属: Homo sapiens

同用名: CMAP

基因 ID: 8530 | 基因类型: protein coding

关于 CST7

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:24,949,269-24,959,928 (from NCBI)

This gene has 1 transcript (splice variant), 191 orthologues and 11 paralogues. Biased expression in bone marrow (RPKM 321.5), spleen (RPKM 27.1) and 1 other tissue.

功能概要

胱抑素超家族包括含有多个胱抑素样序列的蛋白质。一些成员是活性半胱氨酸蛋白酶抑制剂，而其他成员则失去或可能从未获得这种抑制活性。超家族中有三个抑制家族，包括 1 型胱抑素 (stefins) 、2 型胱抑素和激肽原。 2 型胱抑素蛋白是一类半胱氨酸蛋白酶抑制剂，存在于多种人体体液和分泌物中。该基因编码糖基化的半胱氨酸蛋白酶抑制剂，推测其通过抑制造血系统中的独特靶标在免疫调节中发挥作用。已在从恶性肿瘤建立的各种人类癌细胞系中观察到该蛋白的表达。[RefSeq 提供，2008 年 7 月]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine Protease Inhibitors, while Others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human Cancer cell lines established from malignant tumors. [provided by RefSeq, Jul 2008]

CST7 基因产物(1)

mRNA Protein Name
NM_003650.4 NP_003641.3 cystatin-F precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables peptidase inhibitor activity IDA
IDA: 通过直接分析推断
15752368 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18256700 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
15212960 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of peptidase activity IDA
IDA: 通过直接分析推断
15752368 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
18256700 GOA
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
12423348 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
15212960 GOA
located in endosome IDA
IDA: 通过直接分析推断
15752368 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
12423348 GOA
located in lysosome IDA
IDA: 通过直接分析推断
15752368 GOA
located in multivesicular body IDA
IDA: 通过直接分析推断
22365146 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CST7 蛋白结构

Cystatin

Cystatin: Cystatin domain (37 - 133)

  • 0
  • 100
  • 145 a.a.
蛋白主名 其他名称

cystatin-F

cystatin-7

CST7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CST7 O76096 CTSC Homo sapiens P53634
Anti Tag CoIP
18256700
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CST7 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7851 Cystatin F/CST7 Protein, Human (HEK293, His) O76096 (G20-H145) ≥95%

关联疾病

疾病名称 别名
Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy

Hereditary Cerebral Hemorrhage With Amyloidosis

Hchwa

Hereditary Cystatin C Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Familial

Amyloidosis, Cerebroarterial, Icelandic Type

Amyloidosis Vi

Cerebral Hemorrhage, Hereditary, With Amyloidosis

Cst3-Related Cerebral Amyloid Angiopathy

Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant

Caa, Familial

Cerebral Amyloid Angiopathy, Genetic

Acys Amyloidosis

Cst3-Related Amyloidosis

Cystatin Amyloidosis

Hchwa, Icelandic Type

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type

Amyloidosis 6

AMYL6

Acys

Caa

Cerebral Amyloid Angiopathy Cst3-Related

Cerebroarterial Amyloidosis Icelandic Type

Cystatin C Amyloidosis

Hccaa

Hchwai

Hchwa-I

Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type

Cerebral Amyloid Angiopathy Familial

Angiopathy, Amyloid, Cerebral, Cst3-Related

Hereditary Cerebral Amyloid Angiopathy, Icelandic Type

Familial Cerebral Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Hereditary
Papillon-Lefevre Syndrome

Papillon-Lefevre Disease

Papillon-Lefèvre Syndrome

PLS

Keratosis Palmoplantaris With Periodontopathia

PALS

Papillon Lefevre Syndrome

Keratosis Palmoplantar-Periodontopathy Syndrome

Papillon-Lefvre Syndrome

Hyperkeratosis Palmoplantaris With Periodontosis

Keratoris Palmoplantaris With Periodontopathia

Keratosis Palmoplantar - Periodontopathy

Palmar-Plantar Hyperkeratosis And Concomitant Periodontal Destruction

Palmoplantar Keratoderma With Periodontosis

Palsy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03268 CST7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CST7 MGD MGI:1298217
Bos taurus CST7 VGNC VGNC:27777
Rattus norvegicus CST7 RGD RGD:1309154
Felis catus CST7 VGNC VGNC:61237
Canis familiaris CST7 VGNC VGNC:39679
Macaca mulatta CST7 VGNC VGNC:71532
Others CST7 NCBI
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