1. Gene
  2. CAMK1 - calcium/calmodulin dependent protein kinase I Gene

CAMK1 - calcium/calmodulin dependent protein kinase I Gene

中文名称:钙/钙调蛋白依赖性蛋白激酶 I

种属: Homo sapiens

同用名: CAMKI

基因 ID: 8536 | 基因类型: protein coding

关于 CAMK1

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,757,347-9,769,947 (from NCBI)

This gene has 6 transcripts (splice variants), 270 orthologues and 22 paralogues. Broad expression in adrenal (RPKM 42.3), fat (RPKM 25.3) and 22 other tissues.

功能概要

钙/钙调蛋白依赖性蛋白激酶 I 在许多组织中都有表达,并且是钙调蛋白依赖性蛋白激酶级联的一个组成部分。钙/钙调蛋白通过与酶结合直接激活钙/钙调蛋白依赖性蛋白激酶 I,并通过钙/钙调蛋白依赖性蛋白激酶 I 激酶间接促进酶的磷酸化和协同激活。[RefSeq 提供,2008 年 7 月]

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/Calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the Enzyme and indirectly promotes the phosphorylation and synergistic activation of the Enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]

CAMK1 基因产物(1)

mRNA Protein Name
NM_003656.5 NP_003647.1 calcium/calmodulin-dependent protein kinase type 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17442826 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular signal transduction IMP
IMP: 通过突变表型推断
23867755 GOA
involved in negative regulation of protein binding IDA
IDA: 通过直接分析推断
23867755 GOA
involved in positive regulation of dendritic spine development IMP
IMP: 通过突变表型推断
18184567 GOA
involved in positive regulation of muscle cell differentiation IMP
IMP: 通过突变表型推断
11081517 GOA
involved in positive regulation of neuron projection development IDA
IDA: 通过直接分析推断
17442826 GOA
involved in positive regulation of protein export from nucleus IDA
IDA: 通过直接分析推断
23867755 GOA
involved in positive regulation of protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
17442826 GOA
involved in positive regulation of synapse structural plasticity IMP
IMP: 通过突变表型推断
18184567 GOA
involved in positive regulation of syncytium formation by plasma membrane fusion IMP
IMP: 通过突变表型推断
23867755 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
23867755 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
11114197 GOA
involved in regulation of muscle cell differentiation IDA
IDA: 通过直接分析推断
11114197 GOA
involved in regulation of protein binding IDA
IDA: 通过直接分析推断
11114197 GOA
involved in regulation of protein localization IDA
IDA: 通过直接分析推断
11114197 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CAMK1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (22 - 276)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
蛋白主名 其他名称

calcium/calmodulin-dependent protein kinase type 1

caM kinase I alpha

CAMK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CAMK1 Q14012 CAMK1D Homo sapiens Q8IU85 32707033
种属内
CAMK1 Q14012 ATXN1 Homo sapiens P54253 32296183
种属内
CAMK1 Q14012 ATXN1 Homo sapiens P54253 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CAMK1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7714 CAMKI alpha/CAMK1 Protein, Human (HEK293, His) Q14012 (M1-L370) ≥95%

CAMK1 抗体

目录号 产品名 应用 反应物种
HY-P80580 CaMK1 Antibody WB Mouse, Rat

直系同源

种属 基因名 来源 基因 ID
Felis catus CAMK1 VGNC VGNC:60328
Rattus norvegicus CAMK1 RGD RGD:629473
Mus musculus CAMK1 MGD MGI:1098535
Bos taurus CAMK1 VGNC VGNC:26719
Macaca mulatta CAMK1 VGNC VGNC:70522
Canis familiaris CAMK1 VGNC VGNC:38677
Others CAMK1 NCBI