FCN3 - ficolin 3 Gene

中文名称：纤维胶蛋白 3

种属: Homo sapiens

同用名: FCNH; HAKA1

基因 ID: 8547 | 基因类型: protein coding

关于 FCN3

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,369,110-27,374,824 (from NCBI)

This gene has 6 transcripts (splice variants), 52 orthologues, 25 paralogues and is associated with 2 phenotypes. Biased expression in lung (RPKM 93.2), liver (RPKM 47.7) and 3 other tissues.

功能概要

Ficolins 是一组蛋白质，由胶原蛋白样结构域和纤维蛋白原样结构域组成。在人血清中，有两种纤维胶蛋白，它们都具有凝集素活性。由该基因编码的蛋白质是一种不耐热的 β-2-巨糖蛋白，存在于所有人类血清中，是纤维胶蛋白/调理素 p35 凝集素家族的成员。该蛋白质最初是根据其与系统性红斑狼疮患者血清的反应性而确定的，已被证明具有钙非依赖性凝集素活性。该蛋白可以激活与 MASP 和 sMAP 相关的补体途径，从而通过激活凝集素途径帮助宿主防御。可变剪接发生在该位点，并且已经鉴定出两个变体，每个变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]

FCN3 基因产物(2)

mRNA	Protein	Name
NM_003665.4	NP_003656.2	ficolin-3 isoform 1 precursor
NM_173452.3	NP_775628.1	ficolin-3 isoform 2 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables antigen binding	IDA IDA: 通过直接分析推断	22851708	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	19109177	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11907111	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in complement activation	IDA IDA: 通过直接分析推断	22851708	GOA
involved in complement activation, lectin pathway	IDA IDA: 通过直接分析推断	11907111	GOA
involved in defense response to virus	IDA IDA: 通过直接分析推断	22851708	GOA
involved in negative regulation of RNA biosynthetic process	IDA IDA: 通过直接分析推断	22851708	GOA
involved in negative regulation of viral entry into host cell	IMP IMP: 通过突变表型推断	22851708	GOA
involved in positive regulation of opsonization	IDA IDA: 通过直接分析推断	11907111	GOA
involved in proteolysis	IDA IDA: 通过直接分析推断	11907111	GOA
involved in recognition of apoptotic cell	IDA IDA: 通过直接分析推断	15804047	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of serine-type endopeptidase complex	IDA IDA: 通过直接分析推断	11907111	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FCN3 蛋白结构

Collagen

Fibrinogen_C

0
100
200
299 a.a.

蛋白主名

其他名称

ficolin-3

H-ficolin

FCN3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FCN3	O75636	MASP1	Homo sapiens	P48740-2	GMS	23785123
种属内	FCN3	O75636	MASP1	Homo sapiens	P48740-3	GMS	23785123
种属内	FCN3	O75636	FCN2	Homo sapiens	Q15485	Anti Bait CoIP	32094208
种属间	FCN3	O75636	fbpB	Mycobacterium tuberculosis	P9WQP1	Anti Bait CoIP	27141819

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Ficolin 3 Deficiency

Immunodeficiency Due To Ficolin 3 Deficiency	Immunodeficiency Due To Ficolin3 Deficiency
Fcn3 Deficiency	Lcapd3
Lectin Complement Activation Pathway, Defect In, 3	FCN3D
Defect In Lectin Complement Activation Pathway, 3

Rheumatic Heart Disease

Rheumatic Carditis	Rheumatic Congestive Heart Failure
Congestive Rheumatic Heart Failure	Rheumatic Heart Failure
RHD	Rheumatic Fever Inactive Or Quiescent With Heart Disease
Rheumatic Fever Inactive Or Quiescent With Carditis	Organ Rheumatic Heart Disease
Organic Rheumatic Heart Disease	Inactive Rheumatic Heart Disease
Rheumatic Heart	Rheumatic Fever Inactive Or Quiescent With Pancarditis
Rhd - [Rheumatic Heart Disease]	Rheumatic Cardiac Hypertrophy
Rheumatic Fever	Inactive Or Quiescent With Cardiac Hypertrophy
Rheumatic Pancarditis	Inactive Rhd - [Rheumatic Heart Disease]
Rheumatic Nonischaemic Cardiopathy

Rheumatic Fever

Acute Rheumatic Fever	Rhf - Rheumatic Fever
Inflammatory Rheumatism	Active Rheumatic Fever Nos
Acute Active Rheumatic Fever	Subacute Active Rheumatic Fever
Subacute Rheumatic Fever	Active Rheumatic Fever With Unspecified Type Of Heart Involvement
Acute Rheumatic Heart Disease	Active Rheumatic Heart Disease
Acute Organic Rhd - [Rheumatic Heart Disease]	Acute Rhd - [Rheumatic Heart Disease]

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

3mc Syndrome

Craniofacial-Ulnar-Renal Syndrome	Malpuech Facial Clefting Syndrome
Oculopalatoskeletal Syndrome	Carnevale Syndrome
Michels Syndrome	Malpuech-Michels-Mingarelli-Carnevale Syndrome
Carnevale-Krajewska-Fischetto Syndrome	Craniosynostosis With Lid Anomalies
Malpuech Syndrome	Mingarelli Syndrome
Oculo-Skeletal-Abdominal Syndrome	Osa Syndrome
Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia	Ptosis-Strabismus-Rectus Abdominis Diastasis

3mc Syndrome 2

3MC2	Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia
Oculo-Skeletal-Abdominal Syndrome	Osa Syndrome
Carnevale Syndrome	Carnevale Syndrome, Formerly
Carnevale Krajewska Fischetto Syndrome	3mc Syndrome, Type 2

3mc Syndrome 1

Oculopalatoskeletal Syndrome	3MC1
Craniosynostosis With Lid Anomalies	Michels Syndrome, Formerly
Michels Syndrome	3mc Syndrome, Type 1

Pulmonary Aspergilloma

Agammaglobulinemia 4, Autosomal Recessive

Agammaglobulinemia 4	AGM4
Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect	B Cell Linker Protein Deficiency
B-Cell Linker Protein Deficiency	Blnk Deficiency
Agammaglobulinemia Autosomal Recessive Due To Blnk Defect	Agammaglobulinemia, Type 4, Autosomal Recessive

Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Atypical Hemolytic Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To
Ahus	AHUS1
Hemolytic-Uremic Syndrome	Ahus 1
Ahus, Susceptibility To, 1	Hemolytic Uremic Syndrome, Atypical
Non-Shiga-Like Toxin-Associated Hus	Non-Stx-Hus
Nonenteropathic Hus	Atypical Hus
Shiga Toxin-Associated Hemolytic Uremic Syndrome	D+ Hus
Ehec-Hus	Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli
Hemolytic Uremic Syndrome With Diarrhea	Stec-Hus
Shiga-Like Toxin-Associated Hus	Stx-Hus
Typical Hus	Typical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies	Atypical Hus With Anti-Factor H Antibodies
Ahus With Anti-Factor H Antibodies	Ahus With Neutralizing Autoantibodies Against Factor H
Hemolytic Uremic Syndrome Atypical 1	Atypical Hemolytic Uremic Syndrome With H Factor Anomaly
D Hus	Hemolytic-Uremic Syndrome Without Diarrhea
Hemolytic-Uremic Syndrome, Atypical, Type 1	Hemolytic Uremic Syndrome, Typical

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04841	FCN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	FCN3	VGNC	VGNC:72630
Rattus norvegicus	FCN3	RGD	RGD:621221

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FCN3 - ficolin 3 Gene

关于 FCN3

功能概要

FCN3 基因产物(2)

FCN3 蛋白结构

FCN3 蛋白互作信息

关联疾病

直系同源

热门区域

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FCN3 - ficolin 3 Gene

关于 FCN3

功能概要

FCN3 基因产物(2)

FCN3 蛋白结构

FCN3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z