2. Gene
  3. PLPP3 - phospholipid phosphatase 3 Gene

PLPP3 - phospholipid phosphatase 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷脂磷酸酶 3

种属: Homo sapiens

同用名: LPP3; VCIP; Dri42; PAP2B; PPAP2B

基因 ID: 8613 | 基因类型: protein coding

关于 PLPP3

Cytogenetic location: 1p32.2 Genomic coordinates (GRCh38): 1:56,494,761-56,579,563 (from NCBI)

This gene has 5 transcripts (splice variants), 279 orthologues and 9 paralogues. Broad expression in thyroid (RPKM 205.6), placenta (RPKM 102.2) and 23 other tissues.

功能概要

该基因编码的蛋白质是磷脂酸磷酸酶 (PAP) 家族的成员。 PAP 将磷脂酸转化为甘油二酯，并在甘油脂的从头合成以及磷脂酶 D 介导的受体激活信号转导中发挥作用。该蛋白质是一种位于细胞质膜上的膜糖蛋白。它已被证明可以积极水解细胞外溶血磷脂酸和短链磷脂酸。发现该基因的表达在 Hela 细胞中被表皮生长因子增强。[RefSeq 提供，2010 年 3 月]

The protein encoded by this gene is a member of the phosphatidic Acid Phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by Phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]

PLPP3 基因产物(1)

mRNA Protein Name
NM_003713.5 NP_003704.3 phospholipid phosphatase 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ceramide-1-phosphate phosphatase activity IDA
IDA: 通过直接分析推断
9705349 GOA
enables integrin binding IDA
IDA: 通过直接分析推断
12660161 GOA
enables phosphatidate phosphatase activity IDA
IDA: 通过直接分析推断
9305923 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20123964 GOA
enables sphingosine-1-phosphate phosphatase activity IDA
IDA: 通过直接分析推断
9305923 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell-cell adhesion mediated by integrin IDA
IDA: 通过直接分析推断
12660161 GOA
involved in ceramide metabolic process IDA
IDA: 通过直接分析推断
9305923 GOA
involved in homotypic cell-cell adhesion IDA
IDA: 通过直接分析推断
20123964 GOA
acts upstream of integrin-mediated signaling pathway IDA
IDA: 通过直接分析推断
12660161 GOA
involved in negative regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
20123964 GOA
involved in phospholipid dephosphorylation IDA
IDA: 通过直接分析推断
9305923 GOA
involved in phospholipid metabolic process IDA
IDA: 通过直接分析推断
9305923 GOA
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
20123964 GOA
involved in positive regulation of cell-cell adhesion IMP
IMP: 通过突变表型推断
20123964 GOA
involved in positive regulation of endothelial cell migration IMP
IMP: 通过突变表型推断
20123964 GOA
involved in protein stabilization IDA
IDA: 通过直接分析推断
20123964 GOA
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
IMP: 通过突变表型推断
23591818 GOA
involved in sphingosine metabolic process IDA
IDA: 通过直接分析推断
9305923 GOA
involved in wound healing IMP
IMP: 通过突变表型推断
20123964 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
23591818 GOA
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
14527693 GOA
located in endoplasmic reticulum exit site IDA
IDA: 通过直接分析推断
23591818 GOA
located in endoplasmic reticulum-Golgi intermediate compartment membrane IDA
IDA: 通过直接分析推断
23591818 GOA
located in membrane IDA
IDA: 通过直接分析推断
9305923 GOA
located in membrane raft IDA
IDA: 通过直接分析推断
17005594 GOA
located in trans-Golgi network IDA
IDA: 通过直接分析推断
23591818 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PLPP3 蛋白结构

PAP2

PAP2: PAP2 superfamily (131 - 275)

  • 0
  • 100
  • 200
  • 311 a.a.
蛋白主名 其他名称

phospholipid phosphatase 3

PAP2 beta

PLPP3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PLPP3 O14495 CTNND1 Homo sapiens O60716
Pull Down
20123964
种属内
PLPP3 O14495 CTNND1 Homo sapiens O60716
Confocal
20123964
种属内
PLPP3 O14495 CTNND1 Homo sapiens O60716
Anti Tag CoIP
20123964
种属内
PLPP3 O14495 CTNND1 Homo sapiens O60716
Anti Bait CoIP
20123964
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10736 PLPP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PLPP3 VGNC VGNC:100040
Rattus norvegicus PLPP3 RGD RGD:620454
Mus musculus PLPP3 MGD MGI:1915166
Canis familiaris PLPP3 VGNC VGNC:44707
Bos taurus PLPP3 VGNC VGNC:33046
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