1. Gene
  2. CTNND1 - catenin delta 1 Gene

CTNND1 - catenin delta 1 Gene

中文名称:连环蛋白 delta 1

种属: Homo sapiens

同用名: CAS; p120; BCDS2; CTNND; P120CAS; P120CTN; p120(CAS); p120(CTN)

基因 ID: 1500 | 基因类型: protein coding

关于 CTNND1

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,761,802-57,819,540 (from NCBI)

This gene has 52 transcripts (splice variants), 275 orthologues, 6 paralogues and is associated with 74 phenotypes. Ubiquitous expression in esophagus (RPKM 79.1), skin (RPKM 62.3) and 24 other tissues.

功能概要

该基因编码犰狳蛋白家族的一个成员,其在细胞间粘附和信号转导中发挥作用。多个翻译起始密码子和可变剪接导致许多不同的异构体被翻译。并非所有描述的转录本变体的全长性质都已确定。该基因与邻近的上游硫氧还蛋白相关跨膜蛋白 2 (TMX2) 基因之间也存在通读转录。[RefSeq 提供,2010 年 12 月]

This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]

CTNND1 基因产物(22)

mRNA Protein Name
NM_001085458.2 NP_001078927.1 catenin delta-1 isoform 1ABC
NM_001085459.2 NP_001078928.1 catenin delta-1 isoform 1AB
NM_001085460.2 NP_001078929.1 catenin delta-1 isoform 1A
NM_001085461.2 NP_001078930.1 catenin delta-1 isoform 1A
NM_001085462.2 NP_001078931.1 catenin delta-1 isoform 1A
NM_001085463.2 NP_001078932.1 catenin delta-1 isoform 3ABC
NM_001085464.2 NP_001078933.1 catenin delta-1 isoform 3AB
NM_001085465.2 NP_001078934.1 catenin delta-1 isoform 3B
NM_001085466.2 NP_001078935.1 catenin delta-1 isoform 3AC
NM_001085467.2 NP_001078936.1 catenin delta-1 isoform 3A
NM_001085468.2 NP_001078937.1 catenin delta-1 isoform 3A
NM_001085469.2 NP_001078938.1 catenin delta-1 isoform 3A
NM_001206883.2 NP_001193812.1 catenin delta-1 isoform 2ABC
NM_001206884.2 NP_001193813.1 catenin delta-1 isoform 2AC
NM_001206885.2 NP_001193814.1 catenin delta-1 isoform 1AC
NM_001206886.2 NP_001193815.1 catenin delta-1 isoform 2AB
NM_001206887.2 NP_001193816.1 catenin delta-1 isoform 2B
NM_001206888.2 NP_001193817.1 catenin delta-1 isoform 2A
NM_001206889.2 NP_001193818.1 catenin delta-1 isoform 2A
NM_001206890.2 NP_001193819.1 catenin delta-1 isoform 3A
NM_001206891.2 NP_001193820.1 catenin delta-1 isoform 2A
NM_001331.3 NP_001322.1 catenin delta-1 isoform 1B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cadherin binding IDA
IDA: 通过直接分析推断
15240885 GOA
enables cadherin binding IPI
IPI: 通过物理相互作用推断
10725230 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10207085 GOA
enables protein sequestering activity IDA
IDA: 通过直接分析推断
21998202 GOA
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
19332538 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of catenin complex IDA
IDA: 通过直接分析推断
28051089 GOA
is active in cell surface IDA
IDA: 通过直接分析推断
17047063 GOA
located in cell-cell junction IDA
IDA: 通过直接分析推断
12370829 GOA
is active in cytoplasm IDA
IDA: 通过直接分析推断
21998202 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
17047063 GOA
located in cytosol IMP
IMP: 通过突变表型推断
20123964 GOA
located in midbody IDA
IDA: 通过直接分析推断
15166316 GOA
located in nucleus IDA
IDA: 通过直接分析推断
20123964 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
17115030 GOA
located in plasma membrane IMP
IMP: 通过突变表型推断
20123964 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CTNND1 蛋白结构

Arm

Arm: Armadillo/beta-catenin-like repeat (398 - 436)

Arm

Arm: Armadillo/beta-catenin-like repeat (440 - 481)

Arm

Arm: Armadillo/beta-catenin-like repeat (703 - 738)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 968 a.a.
蛋白主名 其他名称

catenin delta-1

cadherin-associated Src substrate

CTNND1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CTNND1 O60716 CDH2 Homo sapiens P19022
Anti Bait CoIP
21357690
种属内
CTNND1 O60716 CDH2 Homo sapiens P19022
Anti Tag CoIP
33961781
种属内
CTNND1 O60716 PTPRJ Homo sapiens Q12913
CoIP
12370829
种属内
CTNND1 O60716 ZBTB33 Homo sapiens Q86T24
Anti Tag CoIP
33961781
种属内
CTNND1 O60716 ZBTB33 Homo sapiens Q86T24
Anti Bait CoIP
10207085
种属内
CTNND1 O60716 EGFR Homo sapiens P00533
Ub Reconstruction
31980649
种属内
CTNND1 O60716 EGFR Homo sapiens P00533
Ub Reconstruction
24658140
种属内
CTNND1 O60716 PLPP3 Homo sapiens O14495
Anti Tag CoIP
20123964
种属内
CTNND1 O60716 PLPP3 Homo sapiens O14495
Far-WB
20123964
种属内
CTNND1 O60716 PLPP3 Homo sapiens O14495
Confocal
20123964
种属内
CTNND1 O60716 PLPP3 Homo sapiens O14495
Anti Bait CoIP
20123964
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Blepharocheilodontic Syndrome 2

BCDS2

Blepharocheilodontic Syndrome, Type 2

Cleft Lip With Or Without Cleft Palate

Tessier Cleft Number 1,2

Blepharocheilodontic Syndrome 1

Blepharocheilodontic Syndrome

Bcd Syndrome

Elschnig Syndrome

Clefting, Ectropion, And Conical Teeth

Lagophthalmia With Bilateral Cleft Lip And Palate

Blepharo-Cheilo-Odontic Syndrome

Bcds

Ectropion, Inferior, With Cleft Lip And/Or Palate

Blepharo-Cheilo-Dontic Syndrome

BCDS1

Ectropion Inferior Cleft Lip And Or Palate

Clefting-Ectropion-Conical Teeth Syndrome

Ectropion Inferior-Cleft Lip And/Or Palate Syndrome

Lagophthalmia-Cleft Lip And Palate Syndrome

Blepharocheilodontic Syndrome, Type 1

Euryblepharon
Pulmonary Sclerosing Hemangioma

Pneumocytoma

Ectropion

Ectropion Of Eyelid

Everted Margin

Eversion Of The Eyelid

Eyelashes Turned Out

Eyelid Everted

Eyelid Turned Out

Unspecified Ectropion Of Unspecified Eye

Distichiasis

Eyelashes, Two Rows Of

Isolated Distichiasis

Cleft Lip

Cheiloschisis

Labium Leporinum

Cleft Lip, Unilateral, Complete

Complete Unilateral Cleft Lip

Hare Lip

Congenital Fissure Of Lip

Isolated Cleft Lip

Cleft Lip Without Cleft Palate

Cleft Lip Without Cleft Palate, Unilateral

Isolated Cleft Lip, Unilateral

Cleft Lip Without Cleft Palate, Bilateral

Isolated Cleft Lip, Bilateral

Esophagus Carcinoma In Situ

Carcinoma In Situ Of Esophagus

Carcinoma In Situ Of Oesophagus

Oesophagus Carcinoma In Situ

Severe Esophageal Dysplasia

Stage 0 Carcinoma Of The Esophagus

Stage 0 Carcinoma Of The Oesophagus

Severe Oesophageal Dysplasia

Lobular Neoplasia

Lobular Carcinoma In Situ

Lobular Carcinoma In Situ Of Breast

Lobular Intraepithelial Neoplasia

Non-Infiltrating Lobular Carcinoma

Noninfiltrating Lobular Carcinoma Unspecified Site

Noninfiltrating Lobular Carcinoma Of Breast

Lobular Carcinoma In Situ Unspecified Site

Colon Adenocarcinoma

Adenocarcinoma Of Colon

Adenocarcinoma Of The Colon

Colonic Adenocarcinoma

Breast Lobular Carcinoma

Cancer, Breast, Lobular

Lobular Breast Carcinoma

Cri-Du-Chat Syndrome

5p Deletion Syndrome

5p Partial Monosomy Syndrome

Monosomy 5p

Cat Cry Syndrome

Chromosome 5p Deletion Syndrome

Cri Du Chat Syndrome

5p- Syndrome

5p Minus Syndrome

Chromosome 5p- Syndrome

Chromosome 5 Short Arm Deletion Syndrome

Chromosome 5p Deletion

Deletion 5p

Cri Du Chat

5p Partial Deletion Syndrome

Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Diffuse Gastric And Lobular Breast Cancer Syndrome

Hereditary Diffuse Gastric Cancer

HDGC

LBC

Familial Diffuse Gastric Cancer

Fdgc

Hereditary Diffuse Gastric Adenocarcinoma

Breast Cancer, Lobular

Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate

DGLBC

Gastric Cancer, Hereditary Diffuse

Gastric Cancer, Familial Diffuse Breast Cancer, Lobular

Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate

E-Cadherin-Associated Hereditary Gastric Cancer

Familial Diffuse Cancer Of Stomach

Hereditary Diffuse Cancer Of Stomach

Gastric Cancer Familial Diffuse

Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate

Cancer, Gastric, Hereditary Diffuse

Diffuse Gastric Cancer

Hereditary Diffuse Gastric Adenocarcinoma

Hereditary Diffuse Gastric Cancer

Signet Cell Adenocarcinoma

Signet Ring Cell Carcinoma

Signet Ring Cell Gastric Carcinoma

Signet Ring Gastric Carcinoma

Fdgc

Familial Diffuse Cancer Of Stomach

Familial Diffuse Gastric Cancer

Gastric Cancer, Familial Diffuse

Gastric Cancer, Hereditary Diffuse

Hdgc

Hereditary Diffuse Cancer Of Stomach

Diffuse Gastric Cancer Syndrome

Cancer, Gastric, Diffuse

Carcinoma, Signet Ring Cell

Gastric Signet Ring Carcinoma

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Ectodermal Dysplasia

Congenital Ectodermal Defect

Congenital Ectodermal Dysplasia

Ectodermal Dysplasia Syndrome

Dysplasia, Ectodermal

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Tooth Agenesis

Oligodontia

Hypodontia

Selective Tooth Agenesis

Tooth Agenesis, Selective

Familial Tooth Agenesis

Anodontia

Congenital Absence Of One Tooth

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CTNND1 VGNC VGNC:71546
Rattus norvegicus CTNND1 RGD RGD:1305643
Mus musculus CTNND1 MGD MGI:105100
Felis catus CTNND1 VGNC VGNC:61258
Bos taurus CTNND1 VGNC VGNC:27805
Canis familiaris CTNND1 VGNC VGNC:103669