CBFA2T3 - CBFA2/RUNX1 partner transcriptional co-repressor 3 Gene

中文名称：CBFA2/RUNX1 伙伴转录辅阻遏物 3

种属: Homo sapiens

同用名: ETO2; MTG16; MTGR2; ZMYND4; RUNX1T3

基因 ID: 863 | 基因类型: protein coding

关于 CBFA2T3

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:88,874,858-88,977,207 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues, 2 paralogues and is associated with 86 phenotypes. Broad expression in spleen (RPKM 6.2), lymph node (RPKM 3.7) and 24 other tissues.

功能概要

该基因编码骨髓易位基因家族的一个成员，该家族与 DNA 结合的转录因子相互作用并募集一系列辅抑制因子以促进转录抑制。 t (16;21) (q24;q22) 易位是急性髓性白血病中不太常见的核型异常之一。易位产生一个嵌合基因，该基因由 runt 相关转录因子 1 基因的 5' 区域与该基因的 3' 区域融合而成。该基因也是推定的乳腺肿瘤抑制基因。可变剪接导致转录物变异。[RefSeq 提供，2010 年 11 月]

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

CBFA2T3 基因产物(2)

mRNA	Protein	Name
NM_005187.6	NP_005178.4	protein CBFA2T3 isoform 1
NM_175931.3	NP_787127.1	protein CBFA2T3 isoform 2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16966434	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within granulocyte differentiation	IDA IDA: 通过直接分析推断	15231665	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	23840896	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	23251453	GOA
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	23840896	GOA
involved in negative regulation of glycolytic process	IDA IDA: 通过直接分析推断	23840896	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	25974097	GOA
involved in regulation of aerobic respiration	IDA IDA: 通过直接分析推断	23840896	GOA
involved in response to hypoxia	IDA IDA: 通过直接分析推断	23840896	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CBFA2T3 蛋白结构

TAFH

NHR2

zf-MYND

0
100
200
300
400
500
600
653 a.a.

蛋白主名

其他名称

protein CBFA2T3

CBFA2/RUNX1 translocation partner 3

CBFA2T3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CBFA2T3	O75081	ZNF652	Homo sapiens	Q9Y2D9	Anti Tag CoIP	16966434
种属内	CBFA2T3	O75081	ZNF652	Homo sapiens	Q9Y2D9	Y2H	16966434

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Acute Megakaryoblastic Leukemia Without Down Syndrome

Non-Ds-Amkl

Childhood Acute Megakaryoblastic Leukemia

Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia

Myeloid Leukemia Associated With Down Syndrome

Myeloid Leukemia

Myeloid Leukaemia	Leukaemia Myelogenous
Leukemia Myelogenous	Myeloid Granulocytic Leukaemia
Myeloid Granulocytic Leukemia	Non-Lymphocytic Leukemia
Leukemia, Myeloid	Granulocytic Leukaemia
Myelogenous Leukaemia	Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Childhood Acute Myeloid Leukemia

Childhood Acute Myeloid Leukaemia	Paediatric Acute Myeloid Leukaemia
Pediatric Acute Myeloid Leukemia

Myeloproliferative Syndrome, Transient

Transient Abnormal Myelopoiesis	Transient Myeloproliferative Syndrome
Transient Myeloproliferative Disease	Mst
Tam	Leukemia, Transient, Of Down Syndrome
Tmd	Leukemia, Transient
Transient Leukemia	Transient Leukemia Of Down Syndrome

Childhood Leukemia

Acute Megakaryocytic Leukemia

Acute Megakaryoblastic Leukemia	Acute Megakaryoblastic Leukaemia
Megakaryocytic Myelosis	Thrombocytic Leukaemia
Amkl	Aml M7
Acute Myeloblastic Leukemia Type 7	Acute Myeloid Leukemia M7
Megakaryoblastic Leukemia Acute	Leukemia, Megakaryoblastic, Acute
Acute Myeloid Leukaemia, M7	Acute Megakaryocytic Leukaemia
Acute Megakaryoblastic Leukaemia, Fab M7	Fab M7
Malignant Megakaryocytosis	M7 - Acute Megakaryoblastic Leukaemia
Megakaryoblastic Leukaemia	Megakaryocytic Leukaemia
Acute Megakaryoblastic Leukaemia, Nos	Acute Megakaryoblastic Leukaemia Without Mention Of Remission

Acute Erythroid Leukemia

Acute Erythroleukemia	Di Guglielmo'S Syndrome
Aml M6	Acute Myeloid Leukemia Fab-M6
Acute Myeloid Leukemia M6	Erythroleukemia
Aml-M6	Acute Erythroleukemia M6a Subtype
Acute Erythroleukemia M6b Subtype	Di Guglielmo Syndrome
Acute Myeloid Leukemia, M6 Type	Acute Erythroblastic Leukemia
Acute Erythroleukemia - M6a Subtype	Acute Erythroleukemia - M6b Subtype
Acute Erythraemia And Erythroleukaemia	Acute Erythroid Leukaemia Without Mention Of Remission
Erythraemia	Erythraemic Myelosis
Erythroleukaemia	Acute Erythraemic Myelosis
Acute Erythraemia

Chromosomal Duplication Syndrome

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01994	CBFA2T3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CBFA2T3	VGNC	VGNC:82569
Mus musculus	CBFA2T3	MGD	MGI:1338013
Rattus norvegicus	CBFA2T3	RGD	RGD:1310547
Macaca mulatta	CBFA2T3	VGNC	VGNC:104685
Canis familiaris	CBFA2T3	VGNC	VGNC:56007
Bos taurus	CBFA2T3	VGNC	VGNC:80260
Others	CBFA2T3	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CBFA2T3 - CBFA2/RUNX1 partner transcriptional co-repressor 3 Gene

关于 CBFA2T3

功能概要

CBFA2T3 基因产物(2)

CBFA2T3 蛋白结构

CBFA2T3 蛋白互作信息

关联疾病

直系同源

热门区域

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CBFA2T3 - CBFA2/RUNX1 partner transcriptional co-repressor 3 Gene

关于 CBFA2T3

功能概要

CBFA2T3 基因产物(2)

CBFA2T3 蛋白结构

CBFA2T3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z