SNX4 - sorting nexin 4 Gene

中文名称：排序 nexin 4

种属: Homo sapiens

同用名: ATG24B

关于 SNX4

功能概要

该基因编码分选连接蛋白家族的一个成员。该家族的成员包含一个 phox (PX) 结构域，它是一个磷酸肌醇结合结构域，并参与细胞内运输。这种蛋白质与瘦素受体的长亚型以及细胞培养物中血小板衍生生长因子、胰岛素和表皮生长因子的受体酪氨酸激酶相关，但其功能未知。这种蛋白质可能与家族成员形成寡聚复合物。已发现该基因的两种转录变体，一种是蛋白质编码，另一种是非蛋白质编码。[RefSeq 提供，2012 年 11 月]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the Leptin receptor and with Receptor Tyrosine Kinases for platelet-derived growth factor, Insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the Other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2012]