2. Gene
  3. TNFSF13 - TNF superfamily member 13 Gene

TNFSF13 - TNF superfamily member 13 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TNF 超家族成员 13

种属: Homo sapiens

同用名: APRIL; CD256; TALL2; ZTNF2; TALL-2; TNLG7B; TRDL-1; UNQ383/PRO715

基因 ID: 8741 | 基因类型: protein coding

关于 TNFSF13

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,558,282-7,561,601 (from NCBI)

This gene has 9 transcripts (splice variants), 97 orthologues and 2 paralogues. Ubiquitous expression in lung (RPKM 37.5), gall bladder (RPKM 25.6) and 25 other tissues.

功能概要

该基因编码的蛋白质是肿瘤坏死因子 (TNF) 配体家族的成员。该蛋白是 TNFRSF17/BCMA 的配体，TNFRSF17/BCMA 是 TNF 受体家族的一员。这种蛋白质及其受体都被发现对 B 细胞发育很重要。体外实验表明，该蛋白可能能够通过与其他 TNF 受体家族蛋白 (如 TNFRSF6/FAS 和 TNFRSF14/HVEM) 的相互作用来诱导细胞凋亡。可变剪接导致多个转录本变体。已经鉴定出一些跳过上游基因 (TNFSF12) 的最后一个外显子并继续进入该基因的第二个外显子的转录本；此类通读转录本包含在 GeneID 407977，TNFSF12-TNFSF13 中。[RefSeq 提供，2010 年 10 月]

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF Receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce Apoptosis through its interaction with other TNF Receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

TNFSF13 基因产物(6)

mRNA Protein Name
NM_001198622.2 NP_001185551.1 tumor necrosis factor ligand superfamily member 13 isoform delta
NM_001198623.2 NP_001185552.1 tumor necrosis factor ligand superfamily member 13 isoform zeta
NM_001198624.2 NP_001185553.1 tumor necrosis factor ligand superfamily member 13 isoform eta
NM_003808.4 NP_003799.1 tumor necrosis factor ligand superfamily member 13 isoform alpha precursor
NM_172087.3 NP_742084.1 tumor necrosis factor ligand superfamily member 13 isoform beta precursor
NM_172088.4 NP_742085.1 tumor necrosis factor ligand superfamily member 13 isoform gamma
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive regulation of isotype switching to IgA isotypes IDA
IDA: 通过直接分析推断
14988498 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19828625 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNFSF13 蛋白结构

TNF

TNF: TNF(Tumour Necrosis Factor) family (147 - 250)

  • 0
  • 100
  • 200
  • 250 a.a.
蛋白主名 其他名称

tumor necrosis factor ligand superfamily member 13

TNF- and APOL-related leukocyte expressed ligand 2

重组 TNFSF13 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70733 APRIL/TNFSF13 Trimer Protein, Human (HEK293, Flag-His) O75888 (K112-L250) ≥95%
HY-P700016AF Animal-Free APRIL/TNFSF13 Protein, Human (His) O75888 (A105-L250) ≥95%
HY-P700661 APRIL/TNFSF13 Trimer Protein, Human (Biotinylated, HEK293, Flag, His-Avi) O75888-1 (K112-L250) ≥95%

关联疾病

疾病名称 别名
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease
Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Connective Tissue Disease

Connective Tissue Diseases

Connective Tissue Disorder

Abnormality Of Connective Tissue

Disorder Of Connective Tissue

Connective Tissue Disorders
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P990070 Zigakibart Inhibitor 98.37% Phase 3
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14823 TNFSF13 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14824 TNFSF13B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TNFSF13 VGNC VGNC:55879
Canis familiaris TNFSF13 VGNC VGNC:97225
Mus musculus TNFSF13 MGD MGI:1916833
Rattus norvegicus TNFSF13 RGD RGD:1305871
Macaca fascicularis TNFSF13 NCBI
Macaca mulatta TNFSF13 NCBI NCBI:100551507
Others TNFSF13 NCBI
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