PABPC4 - poly(A) binding protein cytoplasmic 4 Gene

中文名称：poly (A) 结合蛋白细胞质 4

种属: Homo sapiens

同用名: APP1; APP-1; PABP4; iPABP

关于 PABPC4

功能概要

Poly (A) 结合蛋白 (PABP) 与大多数真核 mRNA 的 3-prime 末端存在的 poly (A) 尾部结合。 PABPC4 或 IPABP (诱导型 PABP) 被分离为编码蛋白质的激活诱导的 T 细胞 mRNA。 T 细胞的激活使 T 细胞中的 PABPC4 mRNA 水平增加了大约 5 倍。 PABPC4 包含 4 个 RNA 结合域和富含脯氨酸的 C 末端。 PABPC4 主要定位于细胞质。这表明 PABPC4 可能是调节活化 T 细胞中不稳定 mRNA 种类的稳定性所必需的。 PABPC4 也被鉴定为一种抗原，APP1 (活化血小板蛋白-1) ，在凝血酶活化的兔血小板上表达。 PABPC4 还可能参与血小板和巨核细胞中蛋白质翻译的调节，或者可能参与血小板致密颗粒中聚腺苷酸的结合或稳定。已发现该基因编码不同亚型的可变剪接转录物变体。还发现这种蛋白质与冠状病毒核衣壳蛋白相互作用，并被认为可以抑制冠状病毒复制。[RefSeq 提供，2021 年 11 月]

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This protein has also been found to interact with coronavirus nucleocapsid proteins and is thought to inhibit coronavirus replication. [provided by RefSeq, Nov 2021]