2. Gene
  3. SUCLG2 - succinate-CoA ligase GDP-forming subunit beta Gene

SUCLG2 - succinate-CoA ligase GDP-forming subunit beta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：琥珀酸辅酶 A 连接酶 GDP 形成亚基β

种属: Homo sapiens

同用名: G-SCS; GBETA; GTPSCS

基因 ID: 8801 | 基因类型: protein coding

关于 SUCLG2

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:67,360,460-67,654,612 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 21.2), kidney (RPKM 16.3) and 25 other tissues.

功能概要

该基因编码琥珀酰辅酶 A 合成酶的 GTP 特异性 β 亚基。琥珀酰辅酶 A 合成酶催化涉及琥珀酰辅酶 A 和琥珀酸形成的可逆反应。交替剪接导致多个转录本变体。该基因的假基因存在于 5 号和 12 号染色体上。[RefSeq 提供，2010 年 4 月]

This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]

SUCLG2 基因产物(2)

mRNA Protein Name
NM_001177599.2 NP_001171070.1 succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 1 precursor
NM_003848.4 NP_003839.2 succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial isoform 2 precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24606901 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of succinate-CoA ligase complex (GDP-forming) IPI
IPI: 通过物理相互作用推断
32627745 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SUCLG2 蛋白结构

ATP-grasp_2

ATP-grasp_2: ATP-grasp domain (39 - 245)

Ligase_CoA

Ligase_CoA: CoA-ligase (307 - 426)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 432 a.a.
蛋白主名 其他名称

succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

GTP-specific succinyl-CoA synthetase beta subunit

SUCLG2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SUCLG2 Q96I99 SUCLG1 Homo sapiens P53597
Anti Tag CoIP
28514442
种属内
SUCLG2 Q96I99 SUCLG1 Homo sapiens P53597
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Vitreous Abscess
Uvulitis

Acute Uvulitis
Ocular Albinism

Albinism, Ocular

Oa

Xloa

Albinism Ocular
Panophthalmitis
Lemierre'S Syndrome

Lemierre Syndrome

Lemierre Postanginal Sepsis

Necrobacillosis

Postanginal Sepsis Secondary To Orophyngeal Infection

Septic Phlebitis Of The Internal Jugular Vein

Fusobacterium Infections

Acute Sore Throat

Human Necrobacillosis

Postanginal Sepsis

Oropharyngeal Infection Leading To Secondary Septic Thrombophlebitis Of The Internal Jugular Vein
Necrotizing Ulcerative Gingivitis

Acute Necrotizing Ulcerative Gingivitis

Anug

Vincent Angina

Vincent'S Disease

Acute Necrotising Ulcerative Gingivitis

Acute Necrotising Ulcerative Gingivostomatitis

Acute Necrotizing Ulcerative Gingivostomatitis

Acute Ulceromembranous Gingivitis

Angina - Vincents

Early Acute Necrotising Gingivitis

Trench Mouth

Vincent'S Angina

Vincent'S Angina - Pharyngitis

Vincent'S Infection, Any Site

Acute Membranous Gingivitis

Fusospirillary Gingivitis

Fusospirillosis

Phagedenic Gingivitis

Vincent'S Gingivitis

Vincent'S Infection

Vincent'S Stomatitis

Gingivitis, Necrotizing Ulcerative
Astigmatism
Purulent Endophthalmitis

Periocular Infection

Acute Endophthalmitis

Endophthalmia

Eye Infestation Nos

Intraocular Infection

Eye Infection Nos
Epiglottitis

Acute Epiglottitis

Acute Epiglottitis And Supraglottitis

Acute Epiglottiditis

Epiglottiditis

Epiglottitis Nos
Night Blindness, Congenital Stationary, Type 1h

Congenital Stationary Night Blindness 1h

CSNB1H

Congenital Stationary Night Blindness Type 1h

Night Blindness, Congenital Stationary, 1h
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14002 SUCLG2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SUCLG2 RGD RGD:1305008
Canis familiaris SUCLG2 VGNC VGNC:46967
Bos taurus SUCLG2 VGNC VGNC:35457
Macaca mulatta SUCLG2 VGNC VGNC:103873
Mus musculus SUCLG2 MGD MGI:1306824
Felis catus SUCLG2 VGNC VGNC:65826
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z