2. Gene
  3. TRIM24 - tripartite motif containing 24 Gene

TRIM24 - tripartite motif containing 24 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含三方基序 24

种属: Homo sapiens

同用名: PTC6; TF1A; TIF1; RNF82; TIF1A; hTIF1; TIF1ALPHA

基因 ID: 8805 | 基因类型: protein coding

关于 TRIM24

Cytogenetic location: 7q33-q34 Genomic coordinates (GRCh38): 7:138,460,259-138,589,996 (from NCBI)

This gene has 6 transcripts (splice variants), 138 orthologues, 80 paralogues and is associated with 75 phenotypes. Ubiquitous expression in testis (RPKM 19.9), ovary (RPKM 16.3) and 25 other tissues.

功能概要

该基因编码的蛋白质通过与几种核受体 (包括雌激素、视黄酸和维生素 D3 受体) 的激活功能 2 (AF2) 区域相互作用来介导转录控制。该蛋白质定位于核体，被认为与染色质和异染色质相关因子有关。该蛋白质是三联基序 (TRIM) 家族的成员。 TRIM 基序包括三个锌结合域——一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2——以及一个卷曲螺旋区域。已针对该基因描述了编码不同同种型的两种可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

TRIM24 基因产物(2)

mRNA Protein Name
NM_003852.4 NP_003843.3 transcription intermediary factor 1-alpha isoform b
NM_015905.3 NP_056989.2 transcription intermediary factor 1-alpha isoform a

TRIM24 蛋白结构

zf-B_box

zf-B_box: B-box zinc finger (159 - 203)

zf-B_box

zf-B_box: B-box zinc finger (220 - 257)

PHD

PHD: PHD-finger (828 - 871)

Bromodomain

Bromodomain: Bromodomain (908 - 988)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1050 a.a.
蛋白主名 其他名称

transcription intermediary factor 1-alpha

E3 ubiquitin-protein ligase TRIM24

重组 TRIM24 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700503 TRIM24 Protein, Human (P. pastoris, His) O15164 (K891-K1012) ≥95%

关联疾病

疾病名称 别名
Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma

Well-Differentiated Thyroid Carcinoma

Differentiated Thyroid Gland Carcinoma
Aortic Malignant Tumor

Aortic Malignant Neoplasm

Malignant Aortic Neoplasm
Adult Dermatomyositis

Adult Onset Dermatomyositis

Adult Type Dermatomyositis
Childhood Type Dermatomyositis

Juvenile Dermatomyositis

Juvenile Dm

Childhood Dermatomyositis

Amyopathic Dermatomyositis

Adm

Dermatomyositis Sine Myositis

Dermatomyositis, Childhood Type
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Laryngeal Small Cell Carcinoma

Small Cell Carcinoma Of Larynx
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-111519 dTRIM24 Inhibitor 99.92% 否
HY-102000B IACS-9571 hydrochloride Inhibitor 99.85% 否
HY-12518 OF-1 Inhibitor 98.28% 否
HY-102000 IACS-9571 Inhibitor / 否
HY-102000A IACS-9571 TFA Inhibitor / 否
HY-143332 TRIM24/BRPF1-IN-2 Inhibitor / 否
HY-161393 RB-CO-PEG5-C2-CO-VH032 / 否
HY-RS15029 TRIM24 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-122626 BRPF1B/TRIM24-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TRIM24 VGNC VGNC:36321
Rattus norvegicus TRIM24 RGD RGD:1560596
Macaca mulatta TRIM24 VGNC VGNC:78562
Mus musculus TRIM24 MGD MGI:109275
Felis catus TRIM24 VGNC VGNC:80746
Canis familiaris TRIM24 VGNC VGNC:51835
Others TRIM24 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z