2. Gene
  3. CD84 - CD84 molecule Gene

CD84 - CD84 molecule Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CD84 分子

种属: Homo sapiens

同用名: LY9B; hCD84; mCD84; SLAMF5

基因 ID: 8832 | 基因类型: protein coding

关于 CD84

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,541,098-160,579,496 (from NCBI)

This gene has 8 transcripts (splice variants), 154 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 12.0), appendix (RPKM 11.0) and 19 other tissues.

功能概要

该基因编码一种膜糖蛋白，它是信号淋巴细胞激活分子 (SLAM) 家族的成员。该家族构成较大的 CD2 细胞表面受体 Ig 超家族的一个子集。编码的蛋白质是一种嗜同性粘附分子，在多种免疫细胞类型中表达，并参与调节这些细胞中受体介导的信号传导。交替剪接导致多个转录本变体。[RefSeq 提供，2011 年 10 月]

This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

CD84 基因产物(5)

mRNA Protein Name
NM_001184879.2 NP_001171808.1 SLAM family member 5 isoform 1 precursor
NM_001184881.2 NP_001171810.1 SLAM family member 5 isoform 3 precursor
NM_001184882.2 NP_001171811.1 SLAM family member 5 isoform 4 precursor
NM_001330742.2 NP_001317671.1 SLAM family member 5 isoform 5 precursor
NM_003874.4 NP_003865.1 SLAM family member 5 isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
17563375 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12928397 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of granulocyte macrophage colony-stimulating factor production IDA
IDA: 通过直接分析推断
22068234 GOA
involved in negative regulation of interleukin-18 production IDA
IDA: 通过直接分析推断
22068234 GOA
involved in negative regulation of mast cell activation IDA
IDA: 通过直接分析推断
22068234 GOA
involved in negative regulation of mast cell degranulation IDA
IDA: 通过直接分析推断
22068234 GOA
involved in regulation of store-operated calcium entry IDA
IDA: 通过直接分析推断
22068234 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CD84 蛋白结构

Ig_3

Ig_3: Immunoglobulin domain (134 - 197)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
蛋白主名 其他名称

SLAM family member 5

CD84 antigen (leukocyte antigen)

CD84 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CD84 Q9UIB8 CD84 Homo sapiens Q9UIB8
GMS
17563375
种属内
CD84 Q9UIB8 CD84 Homo sapiens Q9UIB8
X-Ray Diffraction
17563375
种属内
CD84 Q9UIB8 CD84 Homo sapiens Q9UIB8
Solution Sedimentation
17563375
种属内
CD84 Q9UIB8 SH2D1A Homo sapiens O60880
CoIP
12928397
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CD84 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72414 CD84/SLAMF5 Protein, Human (Biotinylated, HEK293, His-Avi) Q9UIB8-1 (K22-R220) ≥95%
HY-P72463 CD84/SLAMF5 Protein, Human (HEK293, His) Q9UIB8-1 (K22-R220) ≥95%
HY-P78418 CD84/SLAMF5 Protein, Human (HEK293, His-Avi) Q9UIB8-1 (K22-G225) ≥95%

关联疾病

疾病名称 别名
Multisystem Inflammatory Syndrome In Children

Mis-C

Multisystem Inflammatory Disorder In Children And Adolescents

Paediatric Inflammatory Multisystemic Syndrome

Mic
Selective Immunoglobulin Deficiency Disease
Lymphoproliferative Syndrome

Lymphoproliferative Disorder

Lymphoproliferative Disorders

Lymphoproliferative Disorders, Susceptibility To
Dysgammaglobulinemia
Lymphoproliferative Syndrome, X-Linked, 1

Lymphomatoid Papulosis

Duncan Disease

Purtilo Syndrome

X-Linked Lymphoproliferative Syndrome

Xlp

X-Linked Lymphoproliferative Disease

XLP1

Lyp

Lymphoproliferative Disease, X-Linked

Xlpd

X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency

Ebv Infection, Severe, Susceptibility To

Ebvs

Immunodeficiency 5

Imd5

X-Linked Lymphoproliferative Syndrome 1

Epstein-Barr Virus Infection, Familial Fatal

Ebv Infection, Severe

Infectious Mononucleosis, Severe

Infectious Mononucleosis, Severe, Susceptibility To

Immunodeficiency, X-Linked Progressive Combined Variable

Epstein Barr Virus Infection, Familial Fatal

X-Linked Progressive Combined Variable Immunodeficiency 5

Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males

Familial Fatal Epstein-Barr Infection

Severe Susceptibility To Ebv Infection

Severe Susceptibility To Infectious Mononucleosis

Sap Deficiency

Sh2d1a/Slam-Associated Protein Deficiency

X-Linked Lymphoproliferative Syndrome Type 1

X-Linked Progressive Combined Variable Immunodeficiency

Lymphoproliferative Syndrome, X-Linked

Sap

X-Linked Lymphoproliferative Disorder
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02273 CD84 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CD84 VGNC VGNC:38978
Macaca mulatta CD84 VGNC VGNC:70784
Rattus norvegicus CD84 RGD RGD:1564553
Mus musculus CD84 MGD MGI:1336885
Bos taurus CD84 VGNC VGNC:53854
Felis catus CD84 VGNC VGNC:60642
Macaca fascicularis CD84 NCBI NCBI:102136529
Others CD84 NCBI
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