KSR1 - kinase suppressor of ras 1 Gene

中文名称：ras 1 激酶抑制因子

种属: Homo sapiens

同用名: KSR; RSU2

基因 ID: 8844 | 基因类型: protein coding

关于 KSR1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:27,456,448-27,626,435 (from NCBI)

This gene has 20 transcripts (splice variants), 272 orthologues and 23 paralogues. Ubiquitous expression in placenta (RPKM 8.2), endometrium (RPKM 5.8) and 23 other tissues.

功能概要

启用 14-3-3 蛋白结合活性； ATP 结合活性；和蛋白质 C 末端结合活性。参与 MAPK 级联的正调控。位于内质网和膜内。部分含蛋白质复合物。与乳腺癌有关。乳腺癌的生物标志物。 [由基因组资源联盟提供，2022 年 4 月]

Enables 14-3-3 protein binding activity; ATP binding activity; and protein C-terminus binding activity. Involved in positive regulation of MAPK cascade. Located in endoplasmic reticulum and membrane. Part of protein-containing complex. Implicated in breast adenocarcinoma. Biomarker of breast Cancer. [provided by Alliance of Genome Resources, Apr 2022]

KSR1 基因产物(5)

mRNA	Protein	Name
NM_001367810.1	NP_001354739.1	kinase suppressor of Ras 1 isoform 2
NM_001394583.1	NP_001381512.1	kinase suppressor of Ras 1 isoform 3
NM_001394584.1	NP_001381513.1	kinase suppressor of Ras 1 isoform 4
NM_001394585.1	NP_001381514.1	kinase suppressor of Ras 1 isoform 5
NM_014238.2	NP_055053.1	kinase suppressor of Ras 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 14-3-3 protein binding	IDA IDA: 通过直接分析推断	29433126	GOA
enables ATP binding	IDA IDA: 通过直接分析推断	29433126	GOA
enables protein binding	IDA IDA: 通过直接分析推断	22572157	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11909642	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of MAPK cascade	IDA IDA: 通过直接分析推断	29433126	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	22572157	GOA
located in membrane	IDA IDA: 通过直接分析推断	22572157	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	22572157	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KSR1 蛋白结构

Pkinase_Tyr

0
200
400
600
762 a.a.

蛋白主名

其他名称

kinase suppressor of Ras 1

KSR1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	KSR1	Q8IVT5	MAP2K2	Homo sapiens	P36507	Y2H	11909642
种属内	KSR1	Q8IVT5	MAP2K2	Homo sapiens	P36507	Anti Tag CoIP	27086506

种属间: 跨种属相互作用 种属内: 同种属相互作用

KSR1 抗体

目录号	产品名	应用	反应物种
HY-P81646	KSR1 Antibody (YA1391)	WB, IHC-P, ICC/IF, FC	Human, Mouse

关联疾病

疾病名称

别名

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07475	KSR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	KSR1	VGNC	VGNC:74221
Bos taurus	KSR1	VGNC	VGNC:30754
Felis catus	KSR1	VGNC	VGNC:97479
Mus musculus	KSR1	MGD	MGI:105051
Rattus norvegicus	KSR1	RGD	RGD:1308105
Canis familiaris	KSR1	VGNC	VGNC:42547

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KSR1 - kinase suppressor of ras 1 Gene

关于 KSR1

功能概要

KSR1 基因产物(5)

KSR1 蛋白结构

KSR1 蛋白互作信息

KSR1 抗体

关联疾病

直系同源

热门区域

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KSR1 - kinase suppressor of ras 1 Gene

关于 KSR1

功能概要

KSR1 基因产物(5)

KSR1 蛋白结构

KSR1 蛋白互作信息

KSR1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z