TSC22D1 - TSC22 domain family member 1 Gene

中文名称：TSC22 域家族成员 1

种属: Homo sapiens

同用名: Ptg-2; TSC22; TGFB1I4

关于 TSC22D1

功能概要

该基因编码亮氨酸拉链转录因子 TSC22 域家族的成员。编码的蛋白质受转化生长因子β刺激，调节包括 C 型钠尿肽在内的多个基因的转录。编码的蛋白质可能通过诱导癌细胞凋亡在肿瘤抑制中发挥关键作用，并且该基因启动子中的单核苷酸多态性与糖尿病肾病有关。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of Cancer cell Apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]