PER3 - period circadian regulator 3 Gene

中文名称：经期昼夜节律调节器 3

种属: Homo sapiens

同用名: GIG13; FASPS3

基因 ID: 8863 | 基因类型: protein coding

关于 PER3

Cytogenetic location: 1p36.23 Genomic coordinates (GRCh38): 1:7,784,291-7,845,177 (from NCBI)

This gene has 9 transcripts (splice variants), 178 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 14.6), fat (RPKM 11.2) and 24 other tissues.

功能概要

该基因是 Period 基因家族的成员，在视交叉上核 (哺乳动物大脑中的主要昼夜节律起搏器) 中以昼夜节律模式表达。该家族中的基因编码运动活动、新陈代谢和行为的昼夜节律的组成部分。该基因被 CLOCK/ARNTL 异二聚体上调，但随后使用 PER/CRY 异二聚体与 CLOCK/ARNTL 相互作用在反馈回路中抑制这种上调。该基因的多态性与睡眠障碍有关。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2014 年 1 月]

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]

PER3 基因产物(7)

mRNA	Protein	Name
NM_001289861.2	NP_001276790.1	period circadian protein homolog 3 isoform 2
NM_001289862.2	NP_001276791.1	period circadian protein homolog 3 isoform 1
NM_001289863.3	NP_001276792.1	period circadian protein homolog 3 isoform 3
NM_001289864.3	NP_001276793.1	period circadian protein homolog 3 isoform 5
NM_001377275.1	NP_001364204.1	period circadian protein homolog 3 isoform 1
NM_001377276.1	NP_001364205.1	period circadian protein homolog 3 isoform 6
NM_016831.4	NP_058515.1	period circadian protein homolog 3 isoform 4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21070773	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	26903630	GOA
involved in protein stabilization	IMP IMP: 通过突变表型推断	26903630	GOA
involved in regulation of circadian sleep/wake cycle, sleep	IMP IMP: 通过突变表型推断	17346965	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	26903630	GOA
located in nucleus	IDA IDA: 通过直接分析推断	26903630	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

period circadian protein homolog 3

cell growth-inhibiting gene 13 protein

PER3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PER3	P56645	CHEK2	Homo sapiens	O96017	Anti Tag CoIP	21070773
种属内	PER3	P56645	CHEK2	Homo sapiens	O96017	Anti Bait CoIP	21070773
种属内	PER3	P56645	PER1	Homo sapiens	O15534	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Advanced Sleep Phase Syndrome, Familial, 3

Advanced Sleep Phase Syndrome 3	FASPS3
Familial Advanced Sleep Phase Syndrome 3	Sleep Phase Syndrome, Advanced, Familial, Type 3

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Bile Duct Cystadenoma

Cystadenoma Of The Bile Duct

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Gum Cancer

Malignant Neoplasm Of Gum	Malignant Tumor Of Gum
Malignant Gingival Tumor	Malignant Neoplasm Of Other Sites Of Gum
Malignant Tumour Of Gingiva

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Periodic Limb Movement Disorder

Nocturnal Myoclonus Syndrome

Nocturnal Myoclonus

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome	Deletion 1p36
Monosomy 1p36	Subtelomeric 1p36 Deletion
Monosomy 1p36 Syndrome	Distal Monosomy 1p36
Del(1)(P36)	Deletion 1pter
Monosomy 1pter

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10333	PER3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PER3	RGD	RGD:621581
Macaca mulatta	PER3	VGNC	VGNC:100031
Canis familiaris	PER3	VGNC	VGNC:44422
Mus musculus	PER3	MGD	MGI:1277134

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PER3 - period circadian regulator 3 Gene

关于 PER3

功能概要

PER3 基因产物(7)

PER3 蛋白互作信息

关联疾病

直系同源

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PER3 - period circadian regulator 3 Gene

关于 PER3

功能概要

PER3 基因产物(7)

PER3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z