SPHK1 - sphingosine kinase 1 Gene

中文名称：鞘氨醇激酶 1

种属: Homo sapiens

同用名: SPHK

关于 SPHK1

功能概要

由该基因编码的蛋白质催化鞘氨醇磷酸化形成 1-磷酸鞘氨醇 (S1P) ，这是一种具有细胞内和细胞外功能的脂质介质。在细胞内，S1P 调节增殖和存活，在细胞外，它是细胞表面 G 蛋白偶联受体的配体。这种蛋白质及其产物 S1P 在 TNF-α 信号转导和 NF-kappa-B 激活通路中发挥关键作用，而 NF-kappa-B 激活通路在炎症、抗细胞凋亡和免疫过程中很重要。这种蛋白质的磷酸化会改变其催化活性并促进其向质膜的易位。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2017 年 9 月]

The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]