2. Gene
  3. HERC3 - HECT and RLD domain containing E3 ubiquitin protein ligase 3 Gene

HERC3 - HECT and RLD domain containing E3 ubiquitin protein ligase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 HECT 和 RLD 结构域的 E3 泛素蛋白连接酶 3

种属: Homo sapiens

基因 ID: 8916 | 基因类型: protein coding

关于 HERC3

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:88,523,843-88,708,539 (from NCBI)

This gene has 9 transcripts (splice variants), 209 orthologues and 24 paralogues. Ubiquitous expression in prostate (RPKM 6.4), thyroid (RPKM 5.6) and 25 other tissues.

功能概要

该基因编码 HERC 泛素连接酶家族的成员。编码的蛋白质位于胞质溶胶中并通过 HECT 结构域结合泛素。该基因的突变与结直肠癌和胃癌有关。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 10 月]

This gene encodes a member the HERC ubiquitin Ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

HERC3 基因产物(10)

mRNA Protein Name
NM_001271602.2 NP_001258531.1 probable E3 ubiquitin-protein ligase HERC3 isoform 2
NM_001318505.2 NP_001305434.1 probable E3 ubiquitin-protein ligase HERC3 isoform 3
NM_001375477.1 NP_001362406.1 probable E3 ubiquitin-protein ligase HERC3 isoform 4
NM_001375478.1 NP_001362407.1 probable E3 ubiquitin-protein ligase HERC3 isoform 5
NM_001375479.1 NP_001362408.1 probable E3 ubiquitin-protein ligase HERC3 isoform 5
NM_001375480.1 NP_001362409.1 probable E3 ubiquitin-protein ligase HERC3 isoform 6
NM_001375481.1 NP_001362410.1 probable E3 ubiquitin-protein ligase HERC3 isoform 7
NM_001375482.1 NP_001362411.1 probable E3 ubiquitin-protein ligase HERC3 isoform 5
NM_001375483.1 NP_001362412.1 probable E3 ubiquitin-protein ligase HERC3 isoform 5
NM_014606.3 NP_055421.1 probable E3 ubiquitin-protein ligase HERC3 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HERC3 蛋白结构

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (52 - 99)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (103 - 152)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (155 - 205)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (208 - 257)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (260 - 308)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (313 - 376)

HECT

HECT: HECT-domain (ubiquitin-transferase) (753 - 1049)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1050 a.a.
蛋白主名 其他名称

probable E3 ubiquitin-protein ligase HERC3

HECT domain and RCC1-like domain-containing protein 3

HERC3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HERC3 Q15034 RPL23A Homo sapiens P62750
Anti Bait CoIP
35637966
种属内
HERC3 Q15034 RPL23A Homo sapiens P62750
Anti Tag CoIP
35637966
种属内
HERC3 Q15034 RPL23A Homo sapiens P62750
Pull Down
35637966
种属内
HERC3 Q15034 RPL23A Homo sapiens P62750
IF
35637966
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Atypical Follicular Adenoma
Epidural Abscess

Abscess Epidural
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06128 HERC3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus HERC3 MGD MGI:1921248
Bos taurus HERC3 VGNC VGNC:50190
Canis familiaris HERC3 VGNC VGNC:49907
Macaca mulatta HERC3 VGNC VGNC:73365
Rattus norvegicus HERC3 RGD RGD:1307803
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