1. Gene
  2. NAT1 - N-acetyltransferase 1 Gene

NAT1 - N-acetyltransferase 1 Gene

中文名称:N-乙酰转移酶 1

种属: Homo sapiens

同用名: AAC1; MNAT; NATI; NAT-1

基因 ID: 9 | 基因类型: protein coding

关于 NAT1

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:18,170,467-18,223,689 (from NCBI)

This gene has 8 transcripts (splice variants), 310 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 3.6), duodenum (RPKM 2.9) and 23 other tissues.

功能概要

该基因是人类基因组中两个芳胺 N-乙酰转移酶 (NAT) 基因之一,与小鼠和大鼠 Nat2 基因直系同源。由该基因编码的酶催化乙酰基从乙酰辅酶 A 转移到各种芳基胺和肼底物。这种酶有助于代谢药物和其他外源性物质,并在叶酸分解代谢中发挥作用。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供,2011 年 8 月]

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The Enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This Enzyme helps metabolize drugs and Other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

NAT1 基因产物(10)

mRNA Protein Name
NM_000662.8 NP_000653.3 arylamine N-acetyltransferase 1 isoform a
NM_001160170.4 NP_001153642.1 arylamine N-acetyltransferase 1 isoform a
NM_001160171.4 NP_001153643.1 arylamine N-acetyltransferase 1 isoform a
NM_001160172.4 NP_001153644.1 arylamine N-acetyltransferase 1 isoform a
NM_001160173.4 NP_001153645.1 arylamine N-acetyltransferase 1 isoform a
NM_001160174.3 NP_001153646.1 arylamine N-acetyltransferase 1 isoform a
NM_001160175.4 NP_001153647.1 arylamine N-acetyltransferase 1 isoform b
NM_001160176.4 NP_001153648.1 arylamine N-acetyltransferase 1 isoform b
NM_001160179.3 NP_001153651.1 arylamine N-acetyltransferase 1 isoform a
NM_001291962.2 NP_001278891.1 arylamine N-acetyltransferase 1 isoform b
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NAT1 蛋白结构

Acetyltransf_2

Acetyltransf_2: N-acetyltransferase (20 - 280)

  • 0
  • 100
  • 200
  • 290 a.a.
蛋白主名 其他名称

arylamine N-acetyltransferase 1

N-acetyltransferase 1 (arylamine N-acetyltransferase)

NAT1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NAT1 P18440 ICAM1 Homo sapiens P05362 33961781
种属内
NAT1 P18440 ICAM1 Homo sapiens P05362 28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

NAT1 抗体

目录号 产品名 应用 反应物种
HY-P83543 NAT1 Antibody (YA3288) WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder

Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos

Papillary Transitional Carcinoma

Papillary Transitional Cell Carcinoma

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Cholangiocarcinoma

Cholangiocarcinoma, Susceptibility To

Extrahepatic Cholangiocarcinoma

Intrahepatic Cholangiocarcinoma

Chlc

Chlc, Susceptibility To

Cc

Cholangiocarcinoma Of Biliary Tract

Cholangiocellular Carcinoma

Distal Cholangiocarcinoma

Perihilar Cholangiocarcinoma

Bile Duct Cancer

Cca

Adult Primary Cholangiocellular Carcinoma

Bile Duct Carcinoma

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Clubfoot

Congenital Talipes Equinovarus

Congenital Clubfoot

Congenital Equinovarus

Equinovarus Deformity Of Foot

Club Foot

Motor Neuron Disease

Anterior Horn Cell Disease

Motor Neuron Diseases

Mnd - [Motor Neurone Disease]

Lou Gehrig Disease

Creeping Palsy

Creeping Paralysis

Bulbar Motor Neuron Disease

Bulbar Syndrome

Anterior Horn Cell Disorder

Hereditary Motor Neuron Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NAT1 RGD RGD:70490
Macaca mulatta NAT1 VGNC VGNC:75133