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  2. TAF1A - TATA-box binding protein associated factor, RNA polymerase I subunit A Gene

TAF1A - TATA-box binding protein associated factor, RNA polymerase I subunit A Gene

中文名称:TATA-box 结合蛋白相关因子,RNA 聚合酶 I 亚基 A

种属: Homo sapiens

同用名: SL1; RAFI48; TAFI48; MGC:17061

基因 ID: 9015 | 基因类型: protein coding

关于 TAF1A

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:222,554,105-222,589,933 (from NCBI)

This gene has 7 transcripts (splice variants), 201 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 2.3), lymph node (RPKM 1.9) and 24 other tissues.

功能概要

该基因编码 RNA 聚合酶 I 复合物的一个亚基,即选择性因子 I (SLI) 。编码的蛋白质是一种 TATA 盒结合蛋白相关因子,在 RNA 聚合酶 I 预起始复合物的组装中发挥作用。交替剪接导致编码多个亚型的多个转录变体。[RefSeq 提供,2011 年 1 月]

This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]

TAF1A 基因产物(3)

mRNA Protein Name
NM_001201536.1 NP_001188465.1 TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 1
NM_005681.4 NP_005672.1 TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 1
NM_139352.2 NP_647603.1 TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17318177 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase transcription factor SL1 complex IDA
IDA: 通过直接分析推断
11250903 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TAF1A 蛋白结构

TAF1_subA

TAF1_subA: TAF RNA Polymerase I subunit A (12 - 286)

TAF1_subA

TAF1_subA: TAF RNA Polymerase I subunit A (321 - 442)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 450 a.a.
蛋白主名 其他名称

TATA box-binding protein-associated factor RNA polymerase I subunit A

RNA polymerase I-specific TBP-associated factor 48 kDa

TAF1A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TAF1A Q15573 SET Homo sapiens Q01105 17318177
种属内
TAF1A Q15573 SET Homo sapiens Q01105 17318177
种属内
TAF1A Q15573 TAF1B Homo sapiens Q53T94 33961781
种属内
TAF1A Q15573 TAF1B Homo sapiens Q53T94 17318177
种属内
TAF1A Q15573 TBP Homo sapiens P20226 17318177
种属内
TAF1A Q15573 TBP Homo sapiens P20226 33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Familial Isolated Dilated Cardiomyopathy

Familial Or Idiopathic Dilated Cardiomyopathy

Alopecia, Neurologic Defects, And Endocrinopathy Syndrome

Ane Syndrome

ANES

Alopecia-Progressive Neurological Defect-Endocrinopathy Syndrome

Alopecia-Progressive Neurological Defect-Endocrinopathy

Endocrine System Diseases

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus TAF1A VGNC VGNC:35569
Felis catus TAF1A VGNC VGNC:65927
Macaca mulatta TAF1A VGNC VGNC:78087
Canis familiaris TAF1A VGNC VGNC:47077
Mus musculus TAF1A MGD MGI:109578
Rattus norvegicus TAF1A RGD RGD:1305698