CH25H - cholesterol 25-hydroxylase Gene

中文名称：胆固醇 25-羟化酶

种属: Homo sapiens

同用名: C25H

基因 ID: 9023 | 基因类型: protein coding

关于 CH25H

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:89,205,629-89,207,317 (from NCBI)

This gene has 1 transcript (splice variant), 210 orthologues and 3 paralogues.

功能概要

这是一个参与胆固醇和脂质代谢的无内含子基因。编码的蛋白质是一种膜蛋白，包含催化活性所必需的组氨酸残基簇。与大多数其他甾醇羟化酶不同，该酶是利用二铁辅助因子催化疏水底物羟基化的酶小家族的成员。[RefSeq 提供，2008 年 7 月]

This is an intronless gene that is involved in Cholesterol and lipid metabolism. The encoded protein is a membrane protein and contains clusters of histidine residues essential for catalytic activity. Unlike most other sterol hydroxylases, this Enzyme is a member of a small family of Enzymes that utilize diiron cofactors to catalyze the hydroxylation of hydrophobic substrates. [provided by RefSeq, Jul 2008]

CH25H 基因产物(1)

mRNA	Protein	Name
NM_003956.4	NP_003947.1	cholesterol 25-hydroxylase

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cholesterol 25-hydroxylase activity	IDA IDA: 通过直接分析推断	32944968	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cholesterol metabolic process	IDA IDA: 通过直接分析推断	33239446	GOA
involved in negative regulation of fusion of virus membrane with host plasma membrane	IDA IDA: 通过直接分析推断	32944968	GOA
involved in response to type I interferon	IDA IDA: 通过直接分析推断	33239446	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CH25H 蛋白结构

FA_hydroxylase

0
100
200
272 a.a.

蛋白主名

其他名称

cholesterol 25-hydroxylase

cholesterol 25-monooxygenase

关联疾病

疾病名称

别名

Lysosomal Acid Lipase Deficiency

Wolman Disease	Cholesteryl Ester Storage Disease
Lal Deficiency	Lipa Deficiency
Cholesterol Ester Storage Disease	CESD
Cholesterol Ester Hydrolase Deficiency	Acid Lipase Deficiency
Acid Esterase Deficiency	Familial Xanthomatosis
Wolman Xanthomatosis	Wolman'S Disease
Wolman'S Or Triglyceride Storage Type Iii Disease	Xanthomatosis, Familial
Liposomal Acid Lipase Deficiency, Wolman Type	Familial Visceral Xanthomatosis
Primary Familial Xanthomatosis	Primary Familial Xanthomatosis With Adrenal Calcification
Acid Lipase Disease	WOD
Acid Cholesteryl Ester Hydrolase Deficiency, Type 2

Lysosomal And Lipase Deficiency

Cerebrotendinous Xanthomatosis

CTX	Cerebral Cholesterinosis
Cholestanol Storage Disease	Xanthomatosis, Cerebrotendinous
Sterol 27-Hydroxylase Deficiency	Xanthomatosis Cerebrotendinous
Cerebrotendinous Cholesterinosis	Cholestanolosis
Van Bogaert-Scherer-Epstein Disease

Cholesterol Ester Storage Disease

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02589	CH25H Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CH25H	VGNC	VGNC:106022
Rattus norvegicus	CH25H	RGD	RGD:1310575
Mus musculus	CH25H	MGD	MGI:1333869
Canis familiaris	CH25H	VGNC	VGNC:52926
Bos taurus	CH25H	VGNC	VGNC:27261

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CH25H - cholesterol 25-hydroxylase Gene

关于 CH25H

功能概要

CH25H 基因产物(1)

CH25H 蛋白结构

关联疾病

直系同源

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CH25H - cholesterol 25-hydroxylase Gene

关于 CH25H

功能概要

CH25H 基因产物(1)

CH25H 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z